Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result
Introduction and Objectives: Orlistat is a drug widely used in overweight/obese patients, while the combination with l-carnitine could offer an improvement in its effectiveness. To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined.To...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268124002643 |
| _version_ | 1797272463133900800 |
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| author | Saúl A. Vera-Nungaray Miguel Y. Carmona-Castillo María F. Higuera-de la Tijera Livan Delgado-Roche Evelyn Altamirano-Castillo Nancy G. Vega-López Uriel Gutiérrez-Estrada Santiago Camacho-Hernández |
| author_facet | Saúl A. Vera-Nungaray Miguel Y. Carmona-Castillo María F. Higuera-de la Tijera Livan Delgado-Roche Evelyn Altamirano-Castillo Nancy G. Vega-López Uriel Gutiérrez-Estrada Santiago Camacho-Hernández |
| author_sort | Saúl A. Vera-Nungaray |
| collection | DOAJ |
| description | Introduction and Objectives: Orlistat is a drug widely used in overweight/obese patients, while the combination with l-carnitine could offer an improvement in its effectiveness. To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined.To evaluate the effects on the quality of life of patients who took the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Materials and Patients: : We evaluated the quality of life (Short Form-36) in 16 patients [41.81±8.26 (37.77-45.86) years, 81% women] undergoing pharmacotherapy of the combination of orlistat and l-carnitine (once a day) at 4 and 8 weeks of treatment. Data express mean±SD and 95%IC or percentages as correspond. We use paired Student t Test, two tails with an alpha=0.05. Results: Patients lowered their weight by about 3%. Patients show improvement in body pain, general health, vitality and in both Mental [45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46), p=0.02] and Physical [59.4±8.92 (55.03-63.77) vs. 63.36±9.64 (58.63-68.08), p=0.01) summaries. Conclusions: These results suggest a beneficial effect of the combination of Orlistat and l-carnitine on the treatment of overweight. Further studies compared with placebo and standard care are required. |
| first_indexed | 2024-03-07T14:29:42Z |
| format | Article |
| id | doaj.art-125d1e24c288447d982ee65e6b82db88 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-03-07T14:29:42Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-125d1e24c288447d982ee65e6b82db882024-03-06T05:26:19ZengElsevierAnnals of Hepatology1665-26812024-02-0129101470Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary resultSaúl A. Vera-Nungaray0Miguel Y. Carmona-Castillo1María F. Higuera-de la Tijera2Livan Delgado-Roche3Evelyn Altamirano-Castillo4Nancy G. Vega-López5Uriel Gutiérrez-Estrada6Santiago Camacho-Hernández7Gastroenterology Service, General Hospital of Mexico, Mexico City, MexicoGastroenterology Service, General Hospital of Mexico, Mexico City, MexicoGastroenterology Service, General Hospital of Mexico, Mexico City, MexicoClinical Research Manager, Liomont Laboratories, Mexico City, Mexico City, MexicoGeneral Hospital Of Zone 8, Mexican Social Security Institute, Mexico City, MexicoNational Polytechnic Institute, Mexico City, MexicoNational Polytechnic Institute, Mexico City, MexicoGastroenterology Service, General Hospital of Mexico, Mexico City, MexicoIntroduction and Objectives: Orlistat is a drug widely used in overweight/obese patients, while the combination with l-carnitine could offer an improvement in its effectiveness. To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined.To evaluate the effects on the quality of life of patients who took the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Materials and Patients: : We evaluated the quality of life (Short Form-36) in 16 patients [41.81±8.26 (37.77-45.86) years, 81% women] undergoing pharmacotherapy of the combination of orlistat and l-carnitine (once a day) at 4 and 8 weeks of treatment. Data express mean±SD and 95%IC or percentages as correspond. We use paired Student t Test, two tails with an alpha=0.05. Results: Patients lowered their weight by about 3%. Patients show improvement in body pain, general health, vitality and in both Mental [45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46), p=0.02] and Physical [59.4±8.92 (55.03-63.77) vs. 63.36±9.64 (58.63-68.08), p=0.01) summaries. Conclusions: These results suggest a beneficial effect of the combination of Orlistat and l-carnitine on the treatment of overweight. Further studies compared with placebo and standard care are required.http://www.sciencedirect.com/science/article/pii/S1665268124002643 |
| spellingShingle | Saúl A. Vera-Nungaray Miguel Y. Carmona-Castillo María F. Higuera-de la Tijera Livan Delgado-Roche Evelyn Altamirano-Castillo Nancy G. Vega-López Uriel Gutiérrez-Estrada Santiago Camacho-Hernández Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result Annals of Hepatology |
| title | Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result |
| title_full | Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result |
| title_fullStr | Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result |
| title_full_unstemmed | Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result |
| title_short | Effect of the combination of orlistat and l-carnitine on the quality of life (sf-36) in 16 overweigth patients. a preliminary result |
| title_sort | effect of the combination of orlistat and l carnitine on the quality of life sf 36 in 16 overweigth patients a preliminary result |
| url | http://www.sciencedirect.com/science/article/pii/S1665268124002643 |
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