Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model
Objectives: Preeclampsia affects 3%â8% of all pregnancies. Thymoquinone is the primary compound in black cumin (Nigella sativa) and may have potential therapeutic effects in preeclampsia. This research analyses the effects of a black cumin seed ethanol extract on angiotensin II type 1-receptor autoa...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | Journal of Taibah University Medical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1658361217300999 |
| _version_ | 1818310518060875776 |
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| author | Humaira Rahma, Sp.OG I.W.A. Indrawan, Sp.OG Mukhamad Nooryanto, Sp.OG Rahajeng, Sp.OG Kusnarman Keman, Sp.OG |
| author_facet | Humaira Rahma, Sp.OG I.W.A. Indrawan, Sp.OG Mukhamad Nooryanto, Sp.OG Rahajeng, Sp.OG Kusnarman Keman, Sp.OG |
| author_sort | Humaira Rahma, Sp.OG |
| collection | DOAJ |
| description | Objectives: Preeclampsia affects 3%â8% of all pregnancies. Thymoquinone is the primary compound in black cumin (Nigella sativa) and may have potential therapeutic effects in preeclampsia. This research analyses the effects of a black cumin seed ethanol extract on angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and the expression of the endothelin-1 (ET-1) in the placenta in preeclampsia mouse model. Methods: The research design utilizes a post-test only experimental model on a control group design with 6 mice groups (negative control; positive control; and 500, 1000, 1500, and 2000Â mg/kg body weight/day). Result: The results showed a decrease in serum AT1-AA levels and ET-1 expression in the placenta by increased doses of black cumin with an optimal dose of 1000Â mg/kg/day. Conclusions: Black cumin seed ethanol extract reduces AT1-AA serum levels and represses ET-1 expression in the placenta in a preeclampsia mouse model. Keywords: Angiotensin II type 1-receptor autoantibody (AT1-AA), Antioxidant, Black cumin, Endothelin-1 (ET-1) placenta, Preeclampsia, Pregnancy |
| first_indexed | 2024-12-13T07:47:20Z |
| format | Article |
| id | doaj.art-125e858a2c334628b324c71d6d25fcfb |
| institution | Directory Open Access Journal |
| issn | 1658-3612 |
| language | English |
| last_indexed | 2024-12-13T07:47:20Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Taibah University Medical Sciences |
| spelling | doaj.art-125e858a2c334628b324c71d6d25fcfb2022-12-21T23:54:47ZengElsevierJournal of Taibah University Medical Sciences1658-36122017-12-01126528533Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse modelHumaira Rahma, Sp.OG0I.W.A. Indrawan, Sp.OG1Mukhamad Nooryanto, Sp.OG2 Rahajeng, Sp.OG3Kusnarman Keman, Sp.OG4Corresponding address: Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, Indonesia.; Division of Maternal-Fetal Medicine, Department of Obstetric and Gynecology, Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, IndonesiaDivision of Maternal-Fetal Medicine, Department of Obstetric and Gynecology, Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, IndonesiaDivision of Maternal-Fetal Medicine, Department of Obstetric and Gynecology, Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, IndonesiaDivision of Maternal-Fetal Medicine, Department of Obstetric and Gynecology, Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, IndonesiaDivision of Maternal-Fetal Medicine, Department of Obstetric and Gynecology, Faculty of Medicine-Brawijaya University/dr. Saiful Anwar-General Hospital, Malang, IndonesiaObjectives: Preeclampsia affects 3%â8% of all pregnancies. Thymoquinone is the primary compound in black cumin (Nigella sativa) and may have potential therapeutic effects in preeclampsia. This research analyses the effects of a black cumin seed ethanol extract on angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and the expression of the endothelin-1 (ET-1) in the placenta in preeclampsia mouse model. Methods: The research design utilizes a post-test only experimental model on a control group design with 6 mice groups (negative control; positive control; and 500, 1000, 1500, and 2000Â mg/kg body weight/day). Result: The results showed a decrease in serum AT1-AA levels and ET-1 expression in the placenta by increased doses of black cumin with an optimal dose of 1000Â mg/kg/day. Conclusions: Black cumin seed ethanol extract reduces AT1-AA serum levels and represses ET-1 expression in the placenta in a preeclampsia mouse model. Keywords: Angiotensin II type 1-receptor autoantibody (AT1-AA), Antioxidant, Black cumin, Endothelin-1 (ET-1) placenta, Preeclampsia, Pregnancyhttp://www.sciencedirect.com/science/article/pii/S1658361217300999 |
| spellingShingle | Humaira Rahma, Sp.OG I.W.A. Indrawan, Sp.OG Mukhamad Nooryanto, Sp.OG Rahajeng, Sp.OG Kusnarman Keman, Sp.OG Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model Journal of Taibah University Medical Sciences |
| title | Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model |
| title_full | Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model |
| title_fullStr | Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model |
| title_full_unstemmed | Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model |
| title_short | Effect of a black cumin (Nigella sativa) ethanol extract on placental angiotensin II type 1-receptor autoantibody (AT1-AA) serum levels and endothelin-1 (ET-1) expression in a preeclampsia mouse model |
| title_sort | effect of a black cumin nigella sativa ethanol extract on placental angiotensin ii type 1 receptor autoantibody at1 aa serum levels and endothelin 1 et 1 expression in a preeclampsia mouse model |
| url | http://www.sciencedirect.com/science/article/pii/S1658361217300999 |
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