Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space
<p>Abstract</p> <p>Background</p> <p>Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well as to a strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-04-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/5/1/44 |
| _version_ | 1829106866167218176 |
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| author | Konerding Moritz A Wolloscheck Tanja Domeyer Mario Gockel Ines Junginger Theodor |
| author_facet | Konerding Moritz A Wolloscheck Tanja Domeyer Mario Gockel Ines Junginger Theodor |
| author_sort | Konerding Moritz A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well as to a strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses. The objective of our study was to classify the anatomical-surgical layer of the mesopancreas and to describe the surgical principles relevant for resection of the mesopancreas (RMP). Immunohistochemical investigation of the mesopancreatic-perineural lymphogenic structures was carried out with the purpose of identifying possible routes of metastatic spread.</p> <p>Methods</p> <p>Resection of the mesopancreas (RMP) was performed in fresh corpses. Pancreas and mesopancreas were separated from each other and the mesopancreas was immunohistochemically investigated.</p> <p>Results</p> <p>The mesopancreas strains itself dorsally of the mesenteric vessels as a whitish-firm, fatty tissue-like layer. Macroscopically, in the dissected <it>en-bloc </it>specimens of pancreas and mesopancreas nerve plexuses were found running from the dorsal site of the pancreatic head to the mesopancreas to establish a perineural plane. Immunohistochemical examinations revealed the lymphatic vessels localized in direct vicinity of the neuronal plexuses between pancreas and mesopancreas.</p> <p>Conclusion</p> <p>The mesopancreas as a perineural lymphatic layer located dorsally to the pancreas and reaching beyond the mesenteric vessels has not been classified in the anatomical or surgical literature before. The aim to ensure the greatest possible distance from the retropancreatic lymphatic tissue which drains the carcinomatous focus can be achieved in patients with pancreatic cancer only by complete resection of the mesopancreas (RMP).</p> |
| first_indexed | 2024-12-12T06:29:37Z |
| format | Article |
| id | doaj.art-125f9d924b9a496e96f68712287a5fdf |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-12T06:29:37Z |
| publishDate | 2007-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-125f9d924b9a496e96f68712287a5fdf2022-12-22T00:34:38ZengBMCWorld Journal of Surgical Oncology1477-78192007-04-01514410.1186/1477-7819-5-44Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical spaceKonerding Moritz AWolloscheck TanjaDomeyer MarioGockel InesJunginger Theodor<p>Abstract</p> <p>Background</p> <p>Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well as to a strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses. The objective of our study was to classify the anatomical-surgical layer of the mesopancreas and to describe the surgical principles relevant for resection of the mesopancreas (RMP). Immunohistochemical investigation of the mesopancreatic-perineural lymphogenic structures was carried out with the purpose of identifying possible routes of metastatic spread.</p> <p>Methods</p> <p>Resection of the mesopancreas (RMP) was performed in fresh corpses. Pancreas and mesopancreas were separated from each other and the mesopancreas was immunohistochemically investigated.</p> <p>Results</p> <p>The mesopancreas strains itself dorsally of the mesenteric vessels as a whitish-firm, fatty tissue-like layer. Macroscopically, in the dissected <it>en-bloc </it>specimens of pancreas and mesopancreas nerve plexuses were found running from the dorsal site of the pancreatic head to the mesopancreas to establish a perineural plane. Immunohistochemical examinations revealed the lymphatic vessels localized in direct vicinity of the neuronal plexuses between pancreas and mesopancreas.</p> <p>Conclusion</p> <p>The mesopancreas as a perineural lymphatic layer located dorsally to the pancreas and reaching beyond the mesenteric vessels has not been classified in the anatomical or surgical literature before. The aim to ensure the greatest possible distance from the retropancreatic lymphatic tissue which drains the carcinomatous focus can be achieved in patients with pancreatic cancer only by complete resection of the mesopancreas (RMP).</p>http://www.wjso.com/content/5/1/44 |
| spellingShingle | Konerding Moritz A Wolloscheck Tanja Domeyer Mario Gockel Ines Junginger Theodor Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space World Journal of Surgical Oncology |
| title | Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space |
| title_full | Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space |
| title_fullStr | Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space |
| title_full_unstemmed | Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space |
| title_short | Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space |
| title_sort | resection of the mesopancreas rmp a new surgical classification of a known anatomical space |
| url | http://www.wjso.com/content/5/1/44 |
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