Challenges and Advances in Genome Editing Technologies in <i>Streptomyces</i>

Challenges and Advances in Genome Editing Technologies in <i>Streptomyces</i>

The genome of <i>Streptomyces</i> encodes a high number of natural product (NP) biosynthetic gene clusters (BGCs). Most of these BGCs are not expressed or are poorly expressed (commonly called silent BGCs) under traditional laboratory experimental conditions. These NP BGCs represent an u...

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Bibliographic Details
Main Authors: Yawei Zhao, Guoquan Li, Yunliang Chen, Yinhua Lu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomolecules
Subjects:
genome editing
CRISPR/Cas
<i>Streptomyces</i>
microbial natural products
Online Access:https://www.mdpi.com/2218-273X/10/5/734

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