The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis
Highlights Biomarkers of oxidative stress are related to the pathogenesis of preeclampsia and might be indicative of evolving preeclampsia and utilized for timely diagnosis and management of preeclampsia. Systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of oxida...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00436-0 |
| _version_ | 1811344101155536896 |
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| author | Dinara Afrose Hao Chen Amali Ranashinghe Chia-chi Liu Annemarie Henessy Philip M. Hansbro Lana McClements |
| author_facet | Dinara Afrose Hao Chen Amali Ranashinghe Chia-chi Liu Annemarie Henessy Philip M. Hansbro Lana McClements |
| author_sort | Dinara Afrose |
| collection | DOAJ |
| description | Highlights Biomarkers of oxidative stress are related to the pathogenesis of preeclampsia and might be indicative of evolving preeclampsia and utilized for timely diagnosis and management of preeclampsia. Systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of oxidative stress markers based on their diagnostic sensitivities and specificities. Clinically relevant positive predictive values (PPVs) and negative predictive values (NPVs) were determined for each biomarker. IMA, UA, and MDA were associated with 3.38, 3.05, and 2.37 odds ratios for preeclampsia onset. IMA exhibited the most promising diagnostic potential with an average PPV of 0.852 and NPV of 0.811, respectively. Minor heterogeneity was reported for these biomarkers (Higgins’ I 2 = 0–15.879%). These oxidative stress markers should be further explored in larger cohorts for preeclampsia diagnosis. |
| first_indexed | 2024-04-13T19:41:47Z |
| format | Article |
| id | doaj.art-12604cd4c2984b7184f87dfe825ce297 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-13T19:41:47Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-12604cd4c2984b7184f87dfe825ce2972022-12-22T02:32:52ZengBMCBiology of Sex Differences2042-64102022-06-0113111510.1186/s13293-022-00436-0The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysisDinara Afrose0Hao Chen1Amali Ranashinghe2Chia-chi Liu3Annemarie Henessy4Philip M. Hansbro5Lana McClements6School of Life Sciences & Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology SydneySchool of Life Sciences & Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology SydneyFaculty of Science, University of ColomboThe Heart Research Institute, University of SydneyThe Heart Research Institute, University of SydneySchool of Life Sciences & Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology SydneySchool of Life Sciences & Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology SydneyHighlights Biomarkers of oxidative stress are related to the pathogenesis of preeclampsia and might be indicative of evolving preeclampsia and utilized for timely diagnosis and management of preeclampsia. Systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of oxidative stress markers based on their diagnostic sensitivities and specificities. Clinically relevant positive predictive values (PPVs) and negative predictive values (NPVs) were determined for each biomarker. IMA, UA, and MDA were associated with 3.38, 3.05, and 2.37 odds ratios for preeclampsia onset. IMA exhibited the most promising diagnostic potential with an average PPV of 0.852 and NPV of 0.811, respectively. Minor heterogeneity was reported for these biomarkers (Higgins’ I 2 = 0–15.879%). These oxidative stress markers should be further explored in larger cohorts for preeclampsia diagnosis.https://doi.org/10.1186/s13293-022-00436-0PreeclampsiaOxidative stressHeavy metalsBiomarkersMDAIMA |
| spellingShingle | Dinara Afrose Hao Chen Amali Ranashinghe Chia-chi Liu Annemarie Henessy Philip M. Hansbro Lana McClements The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis Biology of Sex Differences Preeclampsia Oxidative stress Heavy metals Biomarkers MDA IMA |
| title | The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis |
| title_full | The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis |
| title_fullStr | The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis |
| title_full_unstemmed | The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis |
| title_short | The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis |
| title_sort | diagnostic potential of oxidative stress biomarkers for preeclampsia systematic review and meta analysis |
| topic | Preeclampsia Oxidative stress Heavy metals Biomarkers MDA IMA |
| url | https://doi.org/10.1186/s13293-022-00436-0 |
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