Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution
Objective: To evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution. Methods: A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=10;spage=464;epage=466;aulast=Lapphra |
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| author | Keswadee Lapphra Rati Diwitaya Sansnee Senawong Maneeprang Thovarabha Parnwas Pinnobphun Alan Maleesatharn Nantaka Kongstan Benjawan Khumcha Wanatpreeya Phongsamart Orasri Wittawatmongkol Supattra Rungmaitree Kulkanya Chokephaibulkit |
| author_facet | Keswadee Lapphra Rati Diwitaya Sansnee Senawong Maneeprang Thovarabha Parnwas Pinnobphun Alan Maleesatharn Nantaka Kongstan Benjawan Khumcha Wanatpreeya Phongsamart Orasri Wittawatmongkol Supattra Rungmaitree Kulkanya Chokephaibulkit |
| author_sort | Keswadee Lapphra |
| collection | DOAJ |
| description | Objective: To evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution.
Methods: A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4 T-lymphocytes >25% or >500 cells/mm3 for at least 6 months. QuantiFERON-TB Gold, T-SPOT.TB, and tuberculin skin test were performed in each patient.
Results: A total of 50 patients were enrolled with median age of 13.7 years, CD4 counts of 753 (IQR: 587-989) cells/mm3. Among 27 patients with tuberculosis (16) or tuberculosis exposure (11), 8 (29.6%) were positive to at least one test, 2 (7.4%) were positive QuantiFERON-TB Gold, 3 (11.1%) positive T-SPOT.TB, and 7 (25.9%) had tuberculin skin test ≥5 mm. Among 23 patients without history of tuberculosis or exposure, all had negative interferon gamma release assays, while 2 (8.7%) had positive tuberculin skin test.
Conclusions: All tests had low sensitivity despite immune reconstitution. |
| first_indexed | 2024-12-20T22:00:24Z |
| format | Article |
| id | doaj.art-12610eb9725c42e7915425dd577e364c |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-12-20T22:00:24Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-12610eb9725c42e7915425dd577e364c2022-12-21T19:25:21ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462020-01-01131046446610.4103/1995-7645.291040Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitutionKeswadee LapphraRati DiwitayaSansnee SenawongManeeprang ThovarabhaParnwas PinnobphunAlan MaleesatharnNantaka KongstanBenjawan KhumchaWanatpreeya PhongsamartOrasri WittawatmongkolSupattra RungmaitreeKulkanya ChokephaibulkitObjective: To evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution. Methods: A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4 T-lymphocytes >25% or >500 cells/mm3 for at least 6 months. QuantiFERON-TB Gold, T-SPOT.TB, and tuberculin skin test were performed in each patient. Results: A total of 50 patients were enrolled with median age of 13.7 years, CD4 counts of 753 (IQR: 587-989) cells/mm3. Among 27 patients with tuberculosis (16) or tuberculosis exposure (11), 8 (29.6%) were positive to at least one test, 2 (7.4%) were positive QuantiFERON-TB Gold, 3 (11.1%) positive T-SPOT.TB, and 7 (25.9%) had tuberculin skin test ≥5 mm. Among 23 patients without history of tuberculosis or exposure, all had negative interferon gamma release assays, while 2 (8.7%) had positive tuberculin skin test. Conclusions: All tests had low sensitivity despite immune reconstitution.http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=10;spage=464;epage=466;aulast=Lapphrachildren; hiv; tb; interferon gamma release assays; tuberculin skin test |
| spellingShingle | Keswadee Lapphra Rati Diwitaya Sansnee Senawong Maneeprang Thovarabha Parnwas Pinnobphun Alan Maleesatharn Nantaka Kongstan Benjawan Khumcha Wanatpreeya Phongsamart Orasri Wittawatmongkol Supattra Rungmaitree Kulkanya Chokephaibulkit Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution Asian Pacific Journal of Tropical Medicine children; hiv; tb; interferon gamma release assays; tuberculin skin test |
| title | Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution |
| title_full | Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution |
| title_fullStr | Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution |
| title_full_unstemmed | Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution |
| title_short | Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution |
| title_sort | performance and correlation of interferon gamma release assays and tuberculin skin test in hiv infected children and adolescents with immune reconstitution |
| topic | children; hiv; tb; interferon gamma release assays; tuberculin skin test |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=10;spage=464;epage=466;aulast=Lapphra |
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