Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood
Cannabis use is common among adolescents and emerging adults and is associated with significant adverse consequences for a subset of users. Rates of use peak between the ages of 18–25, yet the neurobiological consequences for neural systems that are actively developing during this time remain poorly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.951204/full |
| _version_ | 1797984247298916352 |
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| author | Sarah D. Lichenstein Daniel S. Shaw Erika E. Forbes |
| author_facet | Sarah D. Lichenstein Daniel S. Shaw Erika E. Forbes |
| author_sort | Sarah D. Lichenstein |
| collection | DOAJ |
| description | Cannabis use is common among adolescents and emerging adults and is associated with significant adverse consequences for a subset of users. Rates of use peak between the ages of 18–25, yet the neurobiological consequences for neural systems that are actively developing during this time remain poorly understood. In particular, cannabis exposure may interfere with adaptive development of white matter pathways underlying connectivity of the anterior cingulate cortex, including the cingulum and anterior thalamic radiations (ATR). The current study examined the association between cannabis use during adolescence and emerging adulthood and white matter microstructure of the cingulum and ATR among 158 male subjects enrolled in the Pitt Mother and Child Project, a prospective, longitudinal study of risk and resilience among men of low socioeconomic status. Participants were recruited in infancy, completed follow-up assessments throughout childhood and adolescence, and underwent diffusion imaging at ages 20 and 22. At age 20, moderate cannabis use across adolescence (age 12–19) was associated with higher fractional anisotropy (FA) of the cingulum and ATR, relative to both minimal and heavy adolescent use. Longitudinally, moderate and heavy extended cannabis use (age 12–21) was associated with reduced positive change in FA in the cingulum from age 20 to 22, relative to minimal use. These longitudinal results suggest that cannabis exposure may delay cingulum maturation during the transition to adulthood and potentially impact individuals’ functioning later in development. |
| first_indexed | 2024-04-11T06:59:41Z |
| format | Article |
| id | doaj.art-1262c975516c4a929963e3b0c34c7e7a |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-11T06:59:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-1262c975516c4a929963e3b0c34c7e7a2022-12-22T04:38:49ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-11-011610.3389/fnhum.2022.951204951204Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthoodSarah D. Lichenstein0Daniel S. Shaw1Erika E. Forbes2Yale Imaging and Psychopharmacology (YIP) Lab, Department of Psychiatry, Yale School of Medicine, New Haven, CT, United StatesPitt Parents and Children Laboratory (PPCL), Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesAffective Neuroscience and Developmental Psychopathology (ANDP) Lab, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesCannabis use is common among adolescents and emerging adults and is associated with significant adverse consequences for a subset of users. Rates of use peak between the ages of 18–25, yet the neurobiological consequences for neural systems that are actively developing during this time remain poorly understood. In particular, cannabis exposure may interfere with adaptive development of white matter pathways underlying connectivity of the anterior cingulate cortex, including the cingulum and anterior thalamic radiations (ATR). The current study examined the association between cannabis use during adolescence and emerging adulthood and white matter microstructure of the cingulum and ATR among 158 male subjects enrolled in the Pitt Mother and Child Project, a prospective, longitudinal study of risk and resilience among men of low socioeconomic status. Participants were recruited in infancy, completed follow-up assessments throughout childhood and adolescence, and underwent diffusion imaging at ages 20 and 22. At age 20, moderate cannabis use across adolescence (age 12–19) was associated with higher fractional anisotropy (FA) of the cingulum and ATR, relative to both minimal and heavy adolescent use. Longitudinally, moderate and heavy extended cannabis use (age 12–21) was associated with reduced positive change in FA in the cingulum from age 20 to 22, relative to minimal use. These longitudinal results suggest that cannabis exposure may delay cingulum maturation during the transition to adulthood and potentially impact individuals’ functioning later in development.https://www.frontiersin.org/articles/10.3389/fnhum.2022.951204/fullmarijuanawhite matterACCdevelopmentadolescence |
| spellingShingle | Sarah D. Lichenstein Daniel S. Shaw Erika E. Forbes Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood Frontiers in Human Neuroscience marijuana white matter ACC development adolescence |
| title | Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| title_full | Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| title_fullStr | Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| title_full_unstemmed | Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| title_short | Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| title_sort | cannabis connectivity and coming of age associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood |
| topic | marijuana white matter ACC development adolescence |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.951204/full |
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