The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model
Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayincilik
2021-06-01
|
| Series: | Turkish Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-short-term-effect-of-eugenol-on-the-prevention/48285
|
| _version_ | 1797911427770482688 |
|---|---|
| author | Oğuz Kadir Eğilmez Mehmet Güven Sena Genç Elden Özcan Budak Hüseyin Çakıroğlu Halil Elden Ebru Mihriban Güven |
| author_facet | Oğuz Kadir Eğilmez Mehmet Güven Sena Genç Elden Özcan Budak Hüseyin Çakıroğlu Halil Elden Ebru Mihriban Güven |
| author_sort | Oğuz Kadir Eğilmez |
| collection | DOAJ |
| description | Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.Results:In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).Conclusion:Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy. |
| first_indexed | 2024-04-10T11:40:25Z |
| format | Article |
| id | doaj.art-126438a506254d8a89a69e5c0778dad2 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T11:40:25Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-126438a506254d8a89a69e5c0778dad22023-02-15T16:17:34ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742021-06-0159212413210.4274/tao.2021.619613049054The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat ModelOğuz Kadir Eğilmez0Mehmet Güven1Sena Genç Elden2Özcan Budak3Hüseyin Çakıroğlu4Halil Elden5Ebru Mihriban Güven6 Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey Department of Histology and Embryology, Sakarya University Faculty of Medicine, Sakarya, Turkey Sakarya University, Laboratory of Animal Experiments, Sakarya, Turkey Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey Health Sciences High School, Sakarya University, Sakarya, Turkey Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.Results:In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).Conclusion:Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-short-term-effect-of-eugenol-on-the-prevention/48285 tympanic membranemyringosclerosisantioxidantseugenolratsanimal experimentation |
| spellingShingle | Oğuz Kadir Eğilmez Mehmet Güven Sena Genç Elden Özcan Budak Hüseyin Çakıroğlu Halil Elden Ebru Mihriban Güven The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model Turkish Archives of Otorhinolaryngology tympanic membrane myringosclerosis antioxidants eugenol rats animal experimentation |
| title | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
| title_full | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
| title_fullStr | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
| title_full_unstemmed | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
| title_short | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
| title_sort | short term effect of eugenol on the prevention of experimentally induced myringosclerosis in a rat model |
| topic | tympanic membrane myringosclerosis antioxidants eugenol rats animal experimentation |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-short-term-effect-of-eugenol-on-the-prevention/48285
|
| work_keys_str_mv | AT oguzkadiregilmez theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT mehmetguven theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT senagencelden theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT ozcanbudak theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT huseyincakıroglu theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT halilelden theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT ebrumihribanguven theshorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT oguzkadiregilmez shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT mehmetguven shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT senagencelden shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT ozcanbudak shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT huseyincakıroglu shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT halilelden shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel AT ebrumihribanguven shorttermeffectofeugenolonthepreventionofexperimentallyinducedmyringosclerosisinaratmodel |