Cell immunity at pregnant women with autoimmune thyroiditis and gestosis
In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2002-03-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3855 |
| _version_ | 1827992052361592832 |
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| author | A. Sh. Makhmuthodzhayev L. M. Ogorodova I. D. Evtushenko A. V. Holopov E. L. Timoshina E. V. Makhmuthodzhayeva |
| author_facet | A. Sh. Makhmuthodzhayev L. M. Ogorodova I. D. Evtushenko A. V. Holopov E. L. Timoshina E. V. Makhmuthodzhayeva |
| author_sort | A. Sh. Makhmuthodzhayev |
| collection | DOAJ |
| description | In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin. Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16+ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR+ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development. |
| first_indexed | 2024-04-10T01:14:52Z |
| format | Article |
| id | doaj.art-126473944cba4987bf76397c619da8de |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:14:52Z |
| publishDate | 2002-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-126473944cba4987bf76397c619da8de2023-03-13T09:58:00ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842002-03-0111576210.20538/1682-0363-2002-1-57-622462Cell immunity at pregnant women with autoimmune thyroiditis and gestosisA. Sh. Makhmuthodzhayev0L. M. Ogorodova1I. D. Evtushenko2A. V. Holopov3E. L. Timoshina4E. V. Makhmuthodzhayeva5Сибирский государственный медицинский университет; Роддом 4Сибирский государственный медицинский университет; Роддом 4Сибирский государственный медицинский университет; Роддом 4Сибирский государственный медицинский университет; Роддом 4Сибирский государственный медицинский университет; Роддом 4Сибирский государственный медицинский университет; Роддом 4In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin. Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16+ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR+ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.https://bulletin.ssmu.ru/jour/article/view/3855беременностьаутоиммунный тиреоидитгестозт-лимфоцитынатуральные киллеры |
| spellingShingle | A. Sh. Makhmuthodzhayev L. M. Ogorodova I. D. Evtushenko A. V. Holopov E. L. Timoshina E. V. Makhmuthodzhayeva Cell immunity at pregnant women with autoimmune thyroiditis and gestosis Бюллетень сибирской медицины беременность аутоиммунный тиреоидит гестоз т-лимфоциты натуральные киллеры |
| title | Cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| title_full | Cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| title_fullStr | Cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| title_full_unstemmed | Cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| title_short | Cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| title_sort | cell immunity at pregnant women with autoimmune thyroiditis and gestosis |
| topic | беременность аутоиммунный тиреоидит гестоз т-лимфоциты натуральные киллеры |
| url | https://bulletin.ssmu.ru/jour/article/view/3855 |
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