Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways
The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly attribute...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/10/475 |
| _version_ | 1797728462676426752 |
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| author | J. Catharina Duvigneau Harald Esterbauer Andrey V. Kozlov |
| author_facet | J. Catharina Duvigneau Harald Esterbauer Andrey V. Kozlov |
| author_sort | J. Catharina Duvigneau |
| collection | DOAJ |
| description | The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly attributed to excessive product formation. Underrated so far is, however, that HO may exert effects additionally via modulation of the cellular heme levels. Heme, besides being an often-quoted generator of oxidative stress, plays also an important role as a signaling molecule. Heme controls the anti-oxidative defense, circadian rhythms, activity of ion channels, glucose utilization, erythropoiesis, and macrophage function. This broad spectrum of effects depends on its interaction with proteins ranging from transcription factors to enzymes. In degrading heme, HO has the potential to exert effects also via modulation of heme-mediated pathways. In this review, we will discuss the multitude of pathways regulated by heme to enlarge the view on HO and its role in cell physiology. We will further highlight the contribution of HO to pathophysiology, which results from a dysregulated balance between heme and the degradation products formed by HO. |
| first_indexed | 2024-03-12T11:14:17Z |
| format | Article |
| id | doaj.art-12689d111c5e4a308e4aa6de84735d40 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T11:14:17Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-12689d111c5e4a308e4aa6de84735d402023-09-02T02:18:12ZengMDPI AGAntioxidants2076-39212019-10-0181047510.3390/antiox8100475antiox8100475Role of Heme Oxygenase as a Modulator of Heme-Mediated PathwaysJ. Catharina Duvigneau0Harald Esterbauer1Andrey V. Kozlov2Institute for Medical Biochemistry, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, AustriaDepartment of Laboratory Medicine, Medical University of Vienna, 1210 Vienna, AustriaLudwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, AustriaThe heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly attributed to excessive product formation. Underrated so far is, however, that HO may exert effects additionally via modulation of the cellular heme levels. Heme, besides being an often-quoted generator of oxidative stress, plays also an important role as a signaling molecule. Heme controls the anti-oxidative defense, circadian rhythms, activity of ion channels, glucose utilization, erythropoiesis, and macrophage function. This broad spectrum of effects depends on its interaction with proteins ranging from transcription factors to enzymes. In degrading heme, HO has the potential to exert effects also via modulation of heme-mediated pathways. In this review, we will discuss the multitude of pathways regulated by heme to enlarge the view on HO and its role in cell physiology. We will further highlight the contribution of HO to pathophysiology, which results from a dysregulated balance between heme and the degradation products formed by HO.https://www.mdpi.com/2076-3921/8/10/475heme oxygenasefree hemefree ironintracellular signalingoxidative stressbiliverdincarbon monoxide |
| spellingShingle | J. Catharina Duvigneau Harald Esterbauer Andrey V. Kozlov Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways Antioxidants heme oxygenase free heme free iron intracellular signaling oxidative stress biliverdin carbon monoxide |
| title | Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways |
| title_full | Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways |
| title_fullStr | Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways |
| title_full_unstemmed | Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways |
| title_short | Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways |
| title_sort | role of heme oxygenase as a modulator of heme mediated pathways |
| topic | heme oxygenase free heme free iron intracellular signaling oxidative stress biliverdin carbon monoxide |
| url | https://www.mdpi.com/2076-3921/8/10/475 |
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