CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA
The aim of the study was to investigate whether serum levels of interleukin-4 ( IL-4) reflects the clinical disease status and laboratory features of systemic sclerosis (SSc). IL-4 was measured by ELISA in forty patients wilh SSc. We revealed IL-4 (Ю-lOOOpg/ml) in sera from 12 of 40 pts (30%). These...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2002-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/878 |
| _version_ | 1797863035741667328 |
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| author | T A Nevskaya T A Ryazanlzeva N G Guseva |
| author_facet | T A Nevskaya T A Ryazanlzeva N G Guseva |
| author_sort | T A Nevskaya |
| collection | DOAJ |
| description | The aim of the study was to investigate whether serum levels of interleukin-4 ( IL-4) reflects the clinical disease status and laboratory features of systemic sclerosis (SSc). IL-4 was measured by ELISA in forty patients wilh SSc. We revealed IL-4 (Ю-lOOOpg/ml) in sera from 12 of 40 pts (30%). These pts had significantly less duration of disease, the progression of skin and visceral involvement by the time of investigation and a trend lo the greater frequency of lung fibrosis. There was no correlation of IL-4 level with type of SSc. The pts with increased scrum levels of IL-4 had higher levels of circulated immune complexes, y-globulins, but the levels of acute phase reactants (CRP, fibrinogen) were lower compared with the of others. We suggest that serum IL-4 may serve a biologic marker for the progression of skin and lung fibrosis, but the results require confirmation in longitudinal study. |
| first_indexed | 2024-04-09T22:29:08Z |
| format | Article |
| id | doaj.art-126a3146050642c28469a56e81187026 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:29:08Z |
| publishDate | 2002-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-126a3146050642c28469a56e811870262023-03-22T13:45:37ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922002-02-0140191310.14412/1995-4484-2002-741818CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMAT A NevskayaT A RyazanlzevaN G GusevaThe aim of the study was to investigate whether serum levels of interleukin-4 ( IL-4) reflects the clinical disease status and laboratory features of systemic sclerosis (SSc). IL-4 was measured by ELISA in forty patients wilh SSc. We revealed IL-4 (Ю-lOOOpg/ml) in sera from 12 of 40 pts (30%). These pts had significantly less duration of disease, the progression of skin and visceral involvement by the time of investigation and a trend lo the greater frequency of lung fibrosis. There was no correlation of IL-4 level with type of SSc. The pts with increased scrum levels of IL-4 had higher levels of circulated immune complexes, y-globulins, but the levels of acute phase reactants (CRP, fibrinogen) were lower compared with the of others. We suggest that serum IL-4 may serve a biologic marker for the progression of skin and lung fibrosis, but the results require confirmation in longitudinal study.https://rsp.mediar-press.net/rsp/article/view/878интерлейкин-4системная склеродермият лимфоцитыфиброзактивность |
| spellingShingle | T A Nevskaya T A Ryazanlzeva N G Guseva CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA Научно-практическая ревматология интерлейкин-4 системная склеродермия т лимфоциты фиброз активность |
| title | CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA |
| title_full | CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA |
| title_fullStr | CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA |
| title_full_unstemmed | CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA |
| title_short | CLINICAL IMPORTANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA |
| title_sort | clinical importance of interleukin 4 in systemic scleroderma |
| topic | интерлейкин-4 системная склеродермия т лимфоциты фиброз активность |
| url | https://rsp.mediar-press.net/rsp/article/view/878 |
| work_keys_str_mv | AT tanevskaya clinicalimportanceofinterleukin4insystemicscleroderma AT taryazanlzeva clinicalimportanceofinterleukin4insystemicscleroderma AT ngguseva clinicalimportanceofinterleukin4insystemicscleroderma |