Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either. Cell-based studies show that NPC1L1 is a much weaker transporter for phyt...

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Bibliographic Details
Main Authors: Weiqing Tang, Yinyan Ma, Lin Jia, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick C1-Like 1
ATP-binding cassette
phytosterols
sterol absorption
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414531

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