Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective
Mitochondria, the centers of energy metabolism, have been shown to participate in epigenetic regulation of neurodegenerative diseases. Epigenetic modification of nuclear genes encoding mitochondrial proteins has an impact on mitochondria homeostasis, including mitochondrial biogenesis, and quality,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.688789/full |
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| author | Sutong Xu Sutong Xu Xi Zhang Xi Zhang Chenming Liu Chenming Liu Qiulu Liu Qiulu Liu Huazhen Chai Huazhen Chai Yuping Luo Yuping Luo Siguang Li Siguang Li |
| author_facet | Sutong Xu Sutong Xu Xi Zhang Xi Zhang Chenming Liu Chenming Liu Qiulu Liu Qiulu Liu Huazhen Chai Huazhen Chai Yuping Luo Yuping Luo Siguang Li Siguang Li |
| author_sort | Sutong Xu |
| collection | DOAJ |
| description | Mitochondria, the centers of energy metabolism, have been shown to participate in epigenetic regulation of neurodegenerative diseases. Epigenetic modification of nuclear genes encoding mitochondrial proteins has an impact on mitochondria homeostasis, including mitochondrial biogenesis, and quality, which plays role in the pathogenesis of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. On the other hand, intermediate metabolites regulated by mitochondria such as acetyl-CoA and NAD+, in turn, may regulate nuclear epigenome as the substrate for acetylation and a cofactor of deacetylation, respectively. Thus, mitochondria are involved in epigenetic regulation through bidirectional communication between mitochondria and nuclear, which may provide a new strategy for neurodegenerative diseases treatment. In addition, emerging evidence has suggested that the abnormal modification of mitochondria DNA contributes to disease development through mitochondria dysfunction. In this review, we provide an overview of how mitochondria are involved in epigenetic regulation and discuss the mechanisms of mitochondria in regulation of neurodegenerative diseases from epigenetic perspective. |
| first_indexed | 2024-12-16T08:53:01Z |
| format | Article |
| id | doaj.art-126c8560ac294a64b1de8b3d1a7f2701 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T08:53:01Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-126c8560ac294a64b1de8b3d1a7f27012022-12-21T22:37:22ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.688789688789Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic PerspectiveSutong Xu0Sutong Xu1Xi Zhang2Xi Zhang3Chenming Liu4Chenming Liu5Qiulu Liu6Qiulu Liu7Huazhen Chai8Huazhen Chai9Yuping Luo10Yuping Luo11Siguang Li12Siguang Li13Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaStem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaMitochondria, the centers of energy metabolism, have been shown to participate in epigenetic regulation of neurodegenerative diseases. Epigenetic modification of nuclear genes encoding mitochondrial proteins has an impact on mitochondria homeostasis, including mitochondrial biogenesis, and quality, which plays role in the pathogenesis of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. On the other hand, intermediate metabolites regulated by mitochondria such as acetyl-CoA and NAD+, in turn, may regulate nuclear epigenome as the substrate for acetylation and a cofactor of deacetylation, respectively. Thus, mitochondria are involved in epigenetic regulation through bidirectional communication between mitochondria and nuclear, which may provide a new strategy for neurodegenerative diseases treatment. In addition, emerging evidence has suggested that the abnormal modification of mitochondria DNA contributes to disease development through mitochondria dysfunction. In this review, we provide an overview of how mitochondria are involved in epigenetic regulation and discuss the mechanisms of mitochondria in regulation of neurodegenerative diseases from epigenetic perspective.https://www.frontiersin.org/articles/10.3389/fcell.2021.688789/fullmitochondriametabolismmtDNAepigeneticsneurodegenerative diseases |
| spellingShingle | Sutong Xu Sutong Xu Xi Zhang Xi Zhang Chenming Liu Chenming Liu Qiulu Liu Qiulu Liu Huazhen Chai Huazhen Chai Yuping Luo Yuping Luo Siguang Li Siguang Li Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective Frontiers in Cell and Developmental Biology mitochondria metabolism mtDNA epigenetics neurodegenerative diseases |
| title | Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective |
| title_full | Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective |
| title_fullStr | Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective |
| title_full_unstemmed | Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective |
| title_short | Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective |
| title_sort | role of mitochondria in neurodegenerative diseases from an epigenetic perspective |
| topic | mitochondria metabolism mtDNA epigenetics neurodegenerative diseases |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.688789/full |
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