Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention
Abstract Background To explore the clinical benefits of revascularization in patients with different levels of left ventricular ejection fraction (LVEF) from the perspective of quantitative flow ratio (QFR). Methods Patients who underwent successful percutaneous coronary intervention (PCI) and one-y...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-020-01814-5 |
| _version_ | 1818920961322254336 |
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| author | Jiaxin Zhong Qin Chen Long Chen Zhen Ye Huang Chen Jianmin Sun Juchang Hong Mingfang Ye Yuanming Yan Lianglong Chen Yukun Luo |
| author_facet | Jiaxin Zhong Qin Chen Long Chen Zhen Ye Huang Chen Jianmin Sun Juchang Hong Mingfang Ye Yuanming Yan Lianglong Chen Yukun Luo |
| author_sort | Jiaxin Zhong |
| collection | DOAJ |
| description | Abstract Background To explore the clinical benefits of revascularization in patients with different levels of left ventricular ejection fraction (LVEF) from the perspective of quantitative flow ratio (QFR). Methods Patients who underwent successful percutaneous coronary intervention (PCI) and one-year angiographic follow-up were retrospectively screened and computed by QFR analysis. Based on their LVEF, 301 eligible patients were classified into reduced LVEF (≤ 50%, n = 48) and normal LVEF (> 50%, n = 253) groups. Pre-PCI QFR, post-PCI QFR, follow-up QFR, late lumen loss (LLL), LVEF and major adverse cardiovascular and cerebrovascular events (MACCEs) at one year were compared between groups. Results The reduced LVEF group had a lower mean pre-PCI QFR than the normal LVEF group (0.67 ± 0.16 vs. 0.73 ± 0.15, p = 0.004), but no significant difference was found in the post-PCI or one-year follow-up QFR. No association was found between LVEF and QFR at pre-PCI or follow-up. The reduced LVEF group had greater increases in QFR (0.27 ± 0.18 vs. 0.22 ± 0.15, p = 0.043) and LVEF (6.05 ± 9.45% vs. − 0.37 ± 8.11%, p < 0.001) than the normal LVEF group. The LLL results showed no difference between the two groups, indicating a similar degree of restenosis. The reduced LVEF group had a higher incidence of MACCEs (14.6% vs. 4.3%, p = 0.016), which was mainly due to the higher risk of heart failure (6.3% vs. 0%, p = 0.004). Conclusion Compared to the corresponding normal LVEF patients, patients with reduced LVEF who underwent successful PCI were reported to have greater increases in QFR and LVEF, a similar degree of restenosis, and a higher incidence of MACCEs due to a higher risk of heart failure. It seems that patients with reduced LVEF gain more coronary benefits from successful revascularization from the perspective of flow physiology evaluations. |
| first_indexed | 2024-12-20T01:30:04Z |
| format | Article |
| id | doaj.art-126d7b4f8bdb40ec962d592537e1062b |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-20T01:30:04Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-126d7b4f8bdb40ec962d592537e1062b2022-12-21T19:58:08ZengBMCBMC Cardiovascular Disorders1471-22612020-12-012011910.1186/s12872-020-01814-5Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary interventionJiaxin Zhong0Qin Chen1Long Chen2Zhen Ye3Huang Chen4Jianmin Sun5Juchang Hong6Mingfang Ye7Yuanming Yan8Lianglong Chen9Yukun Luo10Department of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalDepartment of Cardiology, Fujian Medical University Union HospitalAbstract Background To explore the clinical benefits of revascularization in patients with different levels of left ventricular ejection fraction (LVEF) from the perspective of quantitative flow ratio (QFR). Methods Patients who underwent successful percutaneous coronary intervention (PCI) and one-year angiographic follow-up were retrospectively screened and computed by QFR analysis. Based on their LVEF, 301 eligible patients were classified into reduced LVEF (≤ 50%, n = 48) and normal LVEF (> 50%, n = 253) groups. Pre-PCI QFR, post-PCI QFR, follow-up QFR, late lumen loss (LLL), LVEF and major adverse cardiovascular and cerebrovascular events (MACCEs) at one year were compared between groups. Results The reduced LVEF group had a lower mean pre-PCI QFR than the normal LVEF group (0.67 ± 0.16 vs. 0.73 ± 0.15, p = 0.004), but no significant difference was found in the post-PCI or one-year follow-up QFR. No association was found between LVEF and QFR at pre-PCI or follow-up. The reduced LVEF group had greater increases in QFR (0.27 ± 0.18 vs. 0.22 ± 0.15, p = 0.043) and LVEF (6.05 ± 9.45% vs. − 0.37 ± 8.11%, p < 0.001) than the normal LVEF group. The LLL results showed no difference between the two groups, indicating a similar degree of restenosis. The reduced LVEF group had a higher incidence of MACCEs (14.6% vs. 4.3%, p = 0.016), which was mainly due to the higher risk of heart failure (6.3% vs. 0%, p = 0.004). Conclusion Compared to the corresponding normal LVEF patients, patients with reduced LVEF who underwent successful PCI were reported to have greater increases in QFR and LVEF, a similar degree of restenosis, and a higher incidence of MACCEs due to a higher risk of heart failure. It seems that patients with reduced LVEF gain more coronary benefits from successful revascularization from the perspective of flow physiology evaluations.https://doi.org/10.1186/s12872-020-01814-5Quantitative flow ratioLeft ventricular ejection fractionPercutaneous coronary interventionFractional flow reserveFlow physiology |
| spellingShingle | Jiaxin Zhong Qin Chen Long Chen Zhen Ye Huang Chen Jianmin Sun Juchang Hong Mingfang Ye Yuanming Yan Lianglong Chen Yukun Luo Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention BMC Cardiovascular Disorders Quantitative flow ratio Left ventricular ejection fraction Percutaneous coronary intervention Fractional flow reserve Flow physiology |
| title | Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| title_full | Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| title_fullStr | Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| title_full_unstemmed | Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| title_short | Physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| title_sort | physiological benefits evaluated by quantitative flow ratio in patients with reduced left ventricular ejection fraction who underwent percutaneous coronary intervention |
| topic | Quantitative flow ratio Left ventricular ejection fraction Percutaneous coronary intervention Fractional flow reserve Flow physiology |
| url | https://doi.org/10.1186/s12872-020-01814-5 |
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