A study of clinicopathological correlation of periorbital hyperpigmentation
Context: “Dark circles” are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses. Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Patients and Methods: Fifty pa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2018;volume=9;issue=4;spage=245;epage=249;aulast=Nayak |
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| author | Chitra S Nayak Atul S Giri Uddhao S Zambare |
| author_facet | Chitra S Nayak Atul S Giri Uddhao S Zambare |
| author_sort | Chitra S Nayak |
| collection | DOAJ |
| description | Context: “Dark circles” are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses. Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Patients and Methods: Fifty patients affected with periorbital melanosis (POM) were enrolled for the study after obtaining informed consent. Details regarding history, demographic data, and physical examination of POM were recorded, and a 2-mm punch skin biopsy was taken from the affected skin under local anesthesia and stained with hematoxylin and eosin (H and E), Fontana Masson (Melanin), Perls Prussian blue (Hemosiderin). Results: Twenty-three (46%) patients with POM had history of chronic illness before developing POM; 18% patients were atopic, 16% had jaundice, 18% had associated pigmentary demarcation lines (PDL) of type F and G, 8% had acanthosis nigricans, 22% patients had anemia, 16% patients gave positive family history of POM, and menstrual irregularity was seen in 16%. Histopathology revealed dermal melanin deposition with melanophages along with predominantly increased epidermal melanin and melanin in vellus follicular epithelium. Prussian blue for hemosiderin was negative in all cases. Conclusions: The study has elicited the multifactorial origin of POM; females are affected more than males. Dermal melanin deposition is a constant feature. Hemosiderin is not found in POM. Increased pigmentation of the vellus follicular epithelium is a feature of POM. |
| first_indexed | 2024-12-23T04:51:17Z |
| format | Article |
| id | doaj.art-126dfe75db6145519608f307dcc375aa |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-23T04:51:17Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-126dfe75db6145519608f307dcc375aa2022-12-21T17:59:26ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782018-01-019424524910.4103/idoj.IDOJ_244_17A study of clinicopathological correlation of periorbital hyperpigmentationChitra S NayakAtul S GiriUddhao S ZambareContext: “Dark circles” are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses. Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Patients and Methods: Fifty patients affected with periorbital melanosis (POM) were enrolled for the study after obtaining informed consent. Details regarding history, demographic data, and physical examination of POM were recorded, and a 2-mm punch skin biopsy was taken from the affected skin under local anesthesia and stained with hematoxylin and eosin (H and E), Fontana Masson (Melanin), Perls Prussian blue (Hemosiderin). Results: Twenty-three (46%) patients with POM had history of chronic illness before developing POM; 18% patients were atopic, 16% had jaundice, 18% had associated pigmentary demarcation lines (PDL) of type F and G, 8% had acanthosis nigricans, 22% patients had anemia, 16% patients gave positive family history of POM, and menstrual irregularity was seen in 16%. Histopathology revealed dermal melanin deposition with melanophages along with predominantly increased epidermal melanin and melanin in vellus follicular epithelium. Prussian blue for hemosiderin was negative in all cases. Conclusions: The study has elicited the multifactorial origin of POM; females are affected more than males. Dermal melanin deposition is a constant feature. Hemosiderin is not found in POM. Increased pigmentation of the vellus follicular epithelium is a feature of POM.http://www.idoj.in/article.asp?issn=2229-5178;year=2018;volume=9;issue=4;spage=245;epage=249;aulast=NayakHemosiderinmelaninmelanophagesperiorbital melanosis |
| spellingShingle | Chitra S Nayak Atul S Giri Uddhao S Zambare A study of clinicopathological correlation of periorbital hyperpigmentation Indian Dermatology Online Journal Hemosiderin melanin melanophages periorbital melanosis |
| title | A study of clinicopathological correlation of periorbital hyperpigmentation |
| title_full | A study of clinicopathological correlation of periorbital hyperpigmentation |
| title_fullStr | A study of clinicopathological correlation of periorbital hyperpigmentation |
| title_full_unstemmed | A study of clinicopathological correlation of periorbital hyperpigmentation |
| title_short | A study of clinicopathological correlation of periorbital hyperpigmentation |
| title_sort | study of clinicopathological correlation of periorbital hyperpigmentation |
| topic | Hemosiderin melanin melanophages periorbital melanosis |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2018;volume=9;issue=4;spage=245;epage=249;aulast=Nayak |
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