Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates
Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2003-09-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/9/9/03-0362_article |
| _version_ | 1818129811914096640 |
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| author | Ping Tim Tsui Man Leung Kwok Hon Yuen Sik To Lai |
| author_facet | Ping Tim Tsui Man Leung Kwok Hon Yuen Sik To Lai |
| author_sort | Ping Tim Tsui |
| collection | DOAJ |
| description | Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41±14 (range 18–83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates. |
| first_indexed | 2024-12-11T07:55:05Z |
| format | Article |
| id | doaj.art-126ff95e11ab49038d4be81981081671 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T07:55:05Z |
| publishDate | 2003-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-126ff95e11ab49038d4be819810816712022-12-22T01:15:14ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-09-01991064106910.3201/eid0909.030362Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic CorrelatesPing Tim TsuiMan Leung KwokHon YuenSik To LaiSevere acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41±14 (range 18–83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates.https://wwwnc.cdc.gov/eid/article/9/9/03-0362_articlesevere acute respiratory syndromeclinical outcomeribavirinsteroidHong KongChina |
| spellingShingle | Ping Tim Tsui Man Leung Kwok Hon Yuen Sik To Lai Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates Emerging Infectious Diseases severe acute respiratory syndrome clinical outcome ribavirin steroid Hong Kong China |
| title | Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates |
| title_full | Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates |
| title_fullStr | Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates |
| title_full_unstemmed | Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates |
| title_short | Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates |
| title_sort | severe acute respiratory syndrome clinical outcome and prognostic correlates |
| topic | severe acute respiratory syndrome clinical outcome ribavirin steroid Hong Kong China |
| url | https://wwwnc.cdc.gov/eid/article/9/9/03-0362_article |
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