One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility
Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T1 positive MRI visibility, MRI contrast agent (CA), Gd(OH)3, is introduced in a new, extremely convenient method. Crucially, GdCl3 is reacted w...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Giant |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666542522000327 |
| _version_ | 1817978218954620928 |
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| author | Yifan Jia Weiwen Yuan Mengmeng Xu Congyi Yang Lei Chen Shuo Wang Paul D. Topham Guoxuan Luo Mo Wang Yong Zhang Guihua Jiang Qianqian Yu LinGe Wang |
| author_facet | Yifan Jia Weiwen Yuan Mengmeng Xu Congyi Yang Lei Chen Shuo Wang Paul D. Topham Guoxuan Luo Mo Wang Yong Zhang Guihua Jiang Qianqian Yu LinGe Wang |
| author_sort | Yifan Jia |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T1 positive MRI visibility, MRI contrast agent (CA), Gd(OH)3, is introduced in a new, extremely convenient method. Crucially, GdCl3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH)3 clusters within a poly(ethylene terephthalate) (PET) matrix. T1 and T2 relaxivities of Gd(OH)3 in PET nanofibers are studied. Well-dispersed Gd(OH)3 (sub-nanometer in size) exhibits 34 times higher T1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH)3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH)3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T1 positive contrast of electrospun fibers of a whole host of other systems. |
| first_indexed | 2024-04-13T22:27:30Z |
| format | Article |
| id | doaj.art-127020fa476d45ebbcee32648573f211 |
| institution | Directory Open Access Journal |
| issn | 2666-5425 |
| language | English |
| last_indexed | 2024-04-13T22:27:30Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Giant |
| spelling | doaj.art-127020fa476d45ebbcee32648573f2112022-12-22T02:27:02ZengElsevierGiant2666-54252022-12-0112100121One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term VisibilityYifan Jia0Weiwen Yuan1Mengmeng Xu2Congyi Yang3Lei Chen4Shuo Wang5Paul D. Topham6Guoxuan Luo7Mo Wang8Yong Zhang9Guihua Jiang10Qianqian Yu11LinGe Wang12South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, ChinaGuangdong Second Provincial General Hospital, Guangzhou 510317, ChinaSouth China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, ChinaSouth China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, ChinaSouth China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, ChinaSouth China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, ChinaChemical Engineering and Applied Chemistry, School of Infrastructure and Sustainable Engineering, College of Engineering and Physical Sciences, Aston University, Birmingham, B4 7ET, UKGuangdong Second Provincial General Hospital, Guangzhou 510317, ChinaGuangdong Second Provincial General Hospital, Guangzhou 510317, ChinaGuangdong Second Provincial General Hospital, Guangzhou 510317, China; Corresponding authors.Guangdong Second Provincial General Hospital, Guangzhou 510317, China; Corresponding authors.South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, China; Corresponding authors.South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, China; Corresponding authors.Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T1 positive MRI visibility, MRI contrast agent (CA), Gd(OH)3, is introduced in a new, extremely convenient method. Crucially, GdCl3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH)3 clusters within a poly(ethylene terephthalate) (PET) matrix. T1 and T2 relaxivities of Gd(OH)3 in PET nanofibers are studied. Well-dispersed Gd(OH)3 (sub-nanometer in size) exhibits 34 times higher T1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH)3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH)3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T1 positive contrast of electrospun fibers of a whole host of other systems.http://www.sciencedirect.com/science/article/pii/S2666542522000327ElectrospinningMagnetic nanofibersMagnetic resonance imagingLong-term visibilityGadoliniumT1 positive contrast |
| spellingShingle | Yifan Jia Weiwen Yuan Mengmeng Xu Congyi Yang Lei Chen Shuo Wang Paul D. Topham Guoxuan Luo Mo Wang Yong Zhang Guihua Jiang Qianqian Yu LinGe Wang One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility Giant Electrospinning Magnetic nanofibers Magnetic resonance imaging Long-term visibility Gadolinium T1 positive contrast |
| title | One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility |
| title_full | One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility |
| title_fullStr | One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility |
| title_full_unstemmed | One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility |
| title_short | One-step Method to Fabricate Poly(ethylene terephthalate)/Gd(OH)3 Magnetic Nanofibers tTowards MRI-active Materials with High T1 Relaxivity and Long-term Visibility |
| title_sort | one step method to fabricate poly ethylene terephthalate gd oh 3 magnetic nanofibers ttowards mri active materials with high t1 relaxivity and long term visibility |
| topic | Electrospinning Magnetic nanofibers Magnetic resonance imaging Long-term visibility Gadolinium T1 positive contrast |
| url | http://www.sciencedirect.com/science/article/pii/S2666542522000327 |
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