Advancement in biomarker based effective diagnosis of neonatal sepsis
AbstractNeonatal sepsis is considered as alarming medical emergency and becomes the common global reason of neonatal mortality. Non-specific symptoms and limitations of conventional diagnostic methods for neonatal sepsis mandate fast and reliable method to diagnose disease for point of care applicat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2252016 |
| _version_ | 1797631166979768320 |
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| author | Neha Gopal Nidhi Chauhan Utkarsh Jain Sujata K. Dass Hari S. Sharma Ramesh Chandra |
| author_facet | Neha Gopal Nidhi Chauhan Utkarsh Jain Sujata K. Dass Hari S. Sharma Ramesh Chandra |
| author_sort | Neha Gopal |
| collection | DOAJ |
| description | AbstractNeonatal sepsis is considered as alarming medical emergency and becomes the common global reason of neonatal mortality. Non-specific symptoms and limitations of conventional diagnostic methods for neonatal sepsis mandate fast and reliable method to diagnose disease for point of care application. Recently, disease specific biomarkers have gained interest for rapid diagnosis that led to the development of electrochemical biosensor with enhanced specificity, sensitivity, cost-effectiveness and user-friendliness. Other than conventional biomarker C-reactive protein to diagnose neonatal sepsis, several potential biomarkers including Procalcitonin (PCT), Serum amyloid A (SAA) and other candidates are extensively investigated. The present review provides insights on advancements and diagnostic abilities of protein and nucleotide based biomarkers with their incorporation in developing electrochemical biosensors by employing novel fabrication strategies. This review provides an overview of most promising biomarker and its capability for neonatal sepsis diagnosis to fulfil future demand to develop electrochemical biosensor for point-of-care applications. |
| first_indexed | 2024-03-11T11:17:09Z |
| format | Article |
| id | doaj.art-1273106582664bdeae59ab0ac4997cdd |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-11T11:17:09Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-1273106582664bdeae59ab0ac4997cdd2023-11-10T17:19:33ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2023-12-0151147649010.1080/21691401.2023.2252016Advancement in biomarker based effective diagnosis of neonatal sepsisNeha Gopal0Nidhi Chauhan1Utkarsh Jain2Sujata K. Dass3Hari S. Sharma4Ramesh Chandra5Department of Chemistry, University of Delhi, Delhi, IndiaAmity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh, IndiaAmity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh, IndiaDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, IndiaDepartment of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center, Rotterdam, The NetherlandsDepartment of Chemistry, University of Delhi, Delhi, IndiaAbstractNeonatal sepsis is considered as alarming medical emergency and becomes the common global reason of neonatal mortality. Non-specific symptoms and limitations of conventional diagnostic methods for neonatal sepsis mandate fast and reliable method to diagnose disease for point of care application. Recently, disease specific biomarkers have gained interest for rapid diagnosis that led to the development of electrochemical biosensor with enhanced specificity, sensitivity, cost-effectiveness and user-friendliness. Other than conventional biomarker C-reactive protein to diagnose neonatal sepsis, several potential biomarkers including Procalcitonin (PCT), Serum amyloid A (SAA) and other candidates are extensively investigated. The present review provides insights on advancements and diagnostic abilities of protein and nucleotide based biomarkers with their incorporation in developing electrochemical biosensors by employing novel fabrication strategies. This review provides an overview of most promising biomarker and its capability for neonatal sepsis diagnosis to fulfil future demand to develop electrochemical biosensor for point-of-care applications.https://www.tandfonline.com/doi/10.1080/21691401.2023.2252016Neonatal sepsisbiomarkernanomaterialselectrochemical biosensordiagnosis |
| spellingShingle | Neha Gopal Nidhi Chauhan Utkarsh Jain Sujata K. Dass Hari S. Sharma Ramesh Chandra Advancement in biomarker based effective diagnosis of neonatal sepsis Artificial Cells, Nanomedicine, and Biotechnology Neonatal sepsis biomarker nanomaterials electrochemical biosensor diagnosis |
| title | Advancement in biomarker based effective diagnosis of neonatal sepsis |
| title_full | Advancement in biomarker based effective diagnosis of neonatal sepsis |
| title_fullStr | Advancement in biomarker based effective diagnosis of neonatal sepsis |
| title_full_unstemmed | Advancement in biomarker based effective diagnosis of neonatal sepsis |
| title_short | Advancement in biomarker based effective diagnosis of neonatal sepsis |
| title_sort | advancement in biomarker based effective diagnosis of neonatal sepsis |
| topic | Neonatal sepsis biomarker nanomaterials electrochemical biosensor diagnosis |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2252016 |
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