Cleavage entropy as quantitative measure of protease specificity.

Cleavage entropy as quantitative measure of protease specificity.

A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We compare our results with known subpocket specifici...

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Bibliographic Details
Main Authors: Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Michael A Margreiter, Gudrun M Spitzer, Hannes G Wallnoefer, Klaus R Liedl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3630115?pdf=render

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