Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis

Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis

Abstract Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions pla...

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Bibliographic Details
Main Authors: Emily Córneo, Monique Michels, Mariane Abatti, Andriele Vieira, Renata Casagrande Gonçalves, Filipe Fernandes Gabriel, Heloisa Borges, Amanda Goulart, Natan da Silva Matos, Diogo Dominguini, Roger Varela, Samira Valvassori, Felipe Dal-Pizzol
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14660-6

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