Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres
ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716521000849 |
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| author | Larissa M. Favarello Marcio Nucci Flavio Queiroz-Telles Thaís Guimarães Mauro J. Salles Teresa C.T. Sukiennik Daniel A. da Matta Analy S.A. Melo Arnaldo L. Colombo |
| author_facet | Larissa M. Favarello Marcio Nucci Flavio Queiroz-Telles Thaís Guimarães Mauro J. Salles Teresa C.T. Sukiennik Daniel A. da Matta Analy S.A. Melo Arnaldo L. Colombo |
| author_sort | Larissa M. Favarello |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown. |
| first_indexed | 2024-12-22T00:27:17Z |
| format | Article |
| id | doaj.art-1276b80f41b544ada916547c0e95ee77 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-22T00:27:17Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-1276b80f41b544ada916547c0e95ee772022-12-21T18:45:02ZengElsevierJournal of Global Antimicrobial Resistance2213-71652021-06-0125199201Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centresLarissa M. Favarello0Marcio Nucci1Flavio Queiroz-Telles2Thaís Guimarães3Mauro J. Salles4Teresa C.T. Sukiennik5Daniel A. da Matta6Analy S.A. Melo7Arnaldo L. Colombo8Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilHospital Universitário da Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilDepartamento de Saúde Coletiva, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, BrazilHospital do Servidor Público Estadual de São Paulo, São Paulo, BrazilEscola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Santa Casa de Misericórdia de São Paulo, São Paulo, BrazilSanta Casa de Misericórdia de Porto Alegre, Porto Alegre, BrazilEscola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilEscola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Corresponding author. Mailing address: Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo 669, 5° floor, CEP 04039-032, Sao Paulo – SP, Brazil. Tel.: +55 11 5576 4985, +55 11 99 151 8390.Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilABSTRACT: Objectives: Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period. Methods: We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. Results: Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins. Conclusion: Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.http://www.sciencedirect.com/science/article/pii/S2213716521000849Candida tropicalisAntifungal resistanceCandidaemiaMALDI-TOF/MSEmergent fungal pathogenFluconazole resistance |
| spellingShingle | Larissa M. Favarello Marcio Nucci Flavio Queiroz-Telles Thaís Guimarães Mauro J. Salles Teresa C.T. Sukiennik Daniel A. da Matta Analy S.A. Melo Arnaldo L. Colombo Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres Journal of Global Antimicrobial Resistance Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance |
| title | Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres |
| title_full | Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres |
| title_fullStr | Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres |
| title_full_unstemmed | Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres |
| title_short | Trends towards lower azole susceptibility among 200 Candida tropicalis bloodstream isolates from Brazilian medical centres |
| title_sort | trends towards lower azole susceptibility among 200 candida tropicalis bloodstream isolates from brazilian medical centres |
| topic | Candida tropicalis Antifungal resistance Candidaemia MALDI-TOF/MS Emergent fungal pathogen Fluconazole resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2213716521000849 |
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