Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed signif...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761623000327 |
| _version_ | 1797387846608224256 |
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| author | Kenji Izumi Witsanu Yortchan Yuka Aizawa Ryota Kobayashi Emi Hoshikawa Yiwei Ling Ayako Suzuki |
| author_facet | Kenji Izumi Witsanu Yortchan Yuka Aizawa Ryota Kobayashi Emi Hoshikawa Yiwei Ling Ayako Suzuki |
| author_sort | Kenji Izumi |
| collection | DOAJ |
| description | Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed. |
| first_indexed | 2024-03-08T22:31:00Z |
| format | Article |
| id | doaj.art-127800d80ef840278b0b7cd855b399c8 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-03-08T22:31:00Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-127800d80ef840278b0b7cd855b399c82023-12-18T04:24:09ZengElsevierJapanese Dental Science Review1882-76162023-12-0159365374Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalentsKenji Izumi0Witsanu Yortchan1Yuka Aizawa2Ryota Kobayashi3Emi Hoshikawa4Yiwei Ling5Ayako Suzuki6Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan; Corresponding author.Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan; Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, ThailandDivision of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan; Division of Oral and Maxillofacial Surgery, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, JapanDivision of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan; Division of Oral and Maxillofacial Surgery, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, JapanDivision of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan; Division of Periodontology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, JapanDivision of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, JapanMany conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed.http://www.sciencedirect.com/science/article/pii/S1882761623000327Oral mucosaTissue engineeringClinical applicationsBiomimeticsScaffold |
| spellingShingle | Kenji Izumi Witsanu Yortchan Yuka Aizawa Ryota Kobayashi Emi Hoshikawa Yiwei Ling Ayako Suzuki Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents Japanese Dental Science Review Oral mucosa Tissue engineering Clinical applications Biomimetics Scaffold |
| title | Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents |
| title_full | Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents |
| title_fullStr | Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents |
| title_full_unstemmed | Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents |
| title_short | Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents |
| title_sort | recent trends and perspectives in reconstruction and regeneration of intra extra oral wounds using tissue engineered oral mucosa equivalents |
| topic | Oral mucosa Tissue engineering Clinical applications Biomimetics Scaffold |
| url | http://www.sciencedirect.com/science/article/pii/S1882761623000327 |
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