Diabetes mellitus: new therapeutic approaches to treat an old disease
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Diabetes mellitus is a widespread disease whose frequency increases constantly and is expected to reach alarming levels by the year 2025. Introd...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
São Paulo State University (UNESP)
2009-01-01
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| Series: | Revista de Ciências Farmacêuticas Básica e Aplicada |
| Subjects: | |
| Online Access: | http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/392 |
| _version_ | 1798027572952432640 |
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| author | I. Gabanyi G. B. Ferreira R. C. Ferreira P. B. Santos M. P. Miranda M. Andreolli L. A. de Castro E. Noda D. Franco A. C.V. Campos E. M.C. Oliveira M. Machado D. Giannella- Neto J. M. Granjeiro S. M.S. Maria-Engler M. L.C. Corrêa-Giannella V. A. Fortuna F. H. Lojudice S. V. Sá K. Krogh L. Labriola T. Genzini I. L. Noronha A. C. Goldberg F. G. Eliaschewitz M. C. Sogayar |
| author_facet | I. Gabanyi G. B. Ferreira R. C. Ferreira P. B. Santos M. P. Miranda M. Andreolli L. A. de Castro E. Noda D. Franco A. C.V. Campos E. M.C. Oliveira M. Machado D. Giannella- Neto J. M. Granjeiro S. M.S. Maria-Engler M. L.C. Corrêa-Giannella V. A. Fortuna F. H. Lojudice S. V. Sá K. Krogh L. Labriola T. Genzini I. L. Noronha A. C. Goldberg F. G. Eliaschewitz M. C. Sogayar |
| author_sort | I. Gabanyi |
| collection | DOAJ |
| description | <p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Diabetes mellitus is a widespread disease whose frequency increases constantly and is expected to reach alarming levels by the year 2025. Introduction of insulin therapy represented a major breakthrough; however, a very strict regimen is required to maintain blood glucose levels within the normal range and to prevent or postpone chronic complications associated with this disease. Frequent hyper- and hypoglycemia seriously affect the quality of life of these patients. Reversion of this situation can only be achieved through whole organ (pancreas) transplant or pancreatic islet transplant, the former being a high-risk surgical procedure, while the latter is a much simpler and may be accomplished in only 20-40 min. The advantages and perspectives of islet cell transplantation will be discussed, in the light of tissue engineering and gene therapy. Ongoing research carried out in our laboratory, aimed at developing clinical cell and molecular therapy protocols for diabetes will also be focused. Keywords: Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals. </p> |
| first_indexed | 2024-04-11T18:53:48Z |
| format | Article |
| id | doaj.art-127804a8470a4697a22bc23d057ce9ff |
| institution | Directory Open Access Journal |
| issn | 1808-4532 2179-443X |
| language | English |
| last_indexed | 2024-04-11T18:53:48Z |
| publishDate | 2009-01-01 |
| publisher | São Paulo State University (UNESP) |
| record_format | Article |
| series | Revista de Ciências Farmacêuticas Básica e Aplicada |
| spelling | doaj.art-127804a8470a4697a22bc23d057ce9ff2022-12-22T04:08:14ZengSão Paulo State University (UNESP)Revista de Ciências Farmacêuticas Básica e Aplicada1808-45322179-443X2009-01-0126118Diabetes mellitus: new therapeutic approaches to treat an old diseaseI. GabanyiG. B. FerreiraR. C. FerreiraP. B. SantosM. P. MirandaM. AndreolliL. A. de CastroE. NodaD. FrancoA. C.V. CamposE. M.C. OliveiraM. MachadoD. Giannella- NetoJ. M. GranjeiroS. M.S. Maria-EnglerM. L.C. Corrêa-GiannellaV. A. FortunaF. H. LojudiceS. V. SáK. KroghL. LabriolaT. GenziniI. L. NoronhaA. C. GoldbergF. G. EliaschewitzM. C. Sogayar<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Diabetes mellitus is a widespread disease whose frequency increases constantly and is expected to reach alarming levels by the year 2025. Introduction of insulin therapy represented a major breakthrough; however, a very strict regimen is required to maintain blood glucose levels within the normal range and to prevent or postpone chronic complications associated with this disease. Frequent hyper- and hypoglycemia seriously affect the quality of life of these patients. Reversion of this situation can only be achieved through whole organ (pancreas) transplant or pancreatic islet transplant, the former being a high-risk surgical procedure, while the latter is a much simpler and may be accomplished in only 20-40 min. The advantages and perspectives of islet cell transplantation will be discussed, in the light of tissue engineering and gene therapy. Ongoing research carried out in our laboratory, aimed at developing clinical cell and molecular therapy protocols for diabetes will also be focused. Keywords: Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals. </p>http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/392Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals |
| spellingShingle | I. Gabanyi G. B. Ferreira R. C. Ferreira P. B. Santos M. P. Miranda M. Andreolli L. A. de Castro E. Noda D. Franco A. C.V. Campos E. M.C. Oliveira M. Machado D. Giannella- Neto J. M. Granjeiro S. M.S. Maria-Engler M. L.C. Corrêa-Giannella V. A. Fortuna F. H. Lojudice S. V. Sá K. Krogh L. Labriola T. Genzini I. L. Noronha A. C. Goldberg F. G. Eliaschewitz M. C. Sogayar Diabetes mellitus: new therapeutic approaches to treat an old disease Revista de Ciências Farmacêuticas Básica e Aplicada Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals |
| title | Diabetes mellitus: new therapeutic approaches to treat an old disease |
| title_full | Diabetes mellitus: new therapeutic approaches to treat an old disease |
| title_fullStr | Diabetes mellitus: new therapeutic approaches to treat an old disease |
| title_full_unstemmed | Diabetes mellitus: new therapeutic approaches to treat an old disease |
| title_short | Diabetes mellitus: new therapeutic approaches to treat an old disease |
| title_sort | diabetes mellitus new therapeutic approaches to treat an old disease |
| topic | Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals |
| url | http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/392 |
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