Prognostic Implications of the Complement Protein C1q in Gliomas
The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the inn...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02366/full |
| _version_ | 1819067306039312384 |
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| author | Alessandro Mangogna Beatrice Belmonte Chiara Agostinis Paola Zacchi Domenico Gerardo Iacopino Anna Martorana Vito Rodolico Deborah Bonazza Fabrizio Zanconati Uday Kishore Roberta Bulla |
| author_facet | Alessandro Mangogna Beatrice Belmonte Chiara Agostinis Paola Zacchi Domenico Gerardo Iacopino Anna Martorana Vito Rodolico Deborah Bonazza Fabrizio Zanconati Uday Kishore Roberta Bulla |
| author_sort | Alessandro Mangogna |
| collection | DOAJ |
| description | The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse grade of gliomas. |
| first_indexed | 2024-12-21T16:16:09Z |
| format | Article |
| id | doaj.art-12799b1790ce4795a6bb0479c6fa0851 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T16:16:09Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-12799b1790ce4795a6bb0479c6fa08512022-12-21T18:57:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-10-011010.3389/fimmu.2019.02366480005Prognostic Implications of the Complement Protein C1q in GliomasAlessandro Mangogna0Beatrice Belmonte1Chiara Agostinis2Paola Zacchi3Domenico Gerardo Iacopino4Anna Martorana5Vito Rodolico6Deborah Bonazza7Fabrizio Zanconati8Uday Kishore9Roberta Bulla10Department of Life Sciences, University of Trieste, Trieste, ItalyHuman Pathology Section, Tumour Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, ItalyInstitute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Burlo Garofolo, Trieste, ItalyDepartment of Life Sciences, University of Trieste, Trieste, ItalyNeurosurgical Unit, Department of Experimental Biomedicine and Clinical Neuroscience, University Hospital, Paolo Giaccone, University of Palermo, Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, ItalyDepartment of Medical, Surgical and Health Science, University of Trieste, Trieste, ItalyDepartment of Medical, Surgical and Health Science, University of Trieste, Trieste, ItalyBiosciences, College of Health and Life Sciences, Brunel University London, London, United KingdomDepartment of Life Sciences, University of Trieste, Trieste, ItalyThe contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse grade of gliomas.https://www.frontiersin.org/article/10.3389/fimmu.2019.02366/fullgliomasC1q complementbioinformatics analysissurvival probabilityprognostic significance of C1q |
| spellingShingle | Alessandro Mangogna Beatrice Belmonte Chiara Agostinis Paola Zacchi Domenico Gerardo Iacopino Anna Martorana Vito Rodolico Deborah Bonazza Fabrizio Zanconati Uday Kishore Roberta Bulla Prognostic Implications of the Complement Protein C1q in Gliomas Frontiers in Immunology gliomas C1q complement bioinformatics analysis survival probability prognostic significance of C1q |
| title | Prognostic Implications of the Complement Protein C1q in Gliomas |
| title_full | Prognostic Implications of the Complement Protein C1q in Gliomas |
| title_fullStr | Prognostic Implications of the Complement Protein C1q in Gliomas |
| title_full_unstemmed | Prognostic Implications of the Complement Protein C1q in Gliomas |
| title_short | Prognostic Implications of the Complement Protein C1q in Gliomas |
| title_sort | prognostic implications of the complement protein c1q in gliomas |
| topic | gliomas C1q complement bioinformatics analysis survival probability prognostic significance of C1q |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02366/full |
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