Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs
Alumina nanoparticles (Al<sub>2</sub>O<sub>3</sub> NPs) can be released in occupational environments in different contexts such as industry, defense, and aerospace. Workers can be exposed by inhalation to these NPs, for instance, through welding fumes or aerosolized propellan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2664 |
| _version_ | 1797474903930175488 |
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| author | Samir Dekali Alexandra Bourgois Sabine François |
| author_facet | Samir Dekali Alexandra Bourgois Sabine François |
| author_sort | Samir Dekali |
| collection | DOAJ |
| description | Alumina nanoparticles (Al<sub>2</sub>O<sub>3</sub> NPs) can be released in occupational environments in different contexts such as industry, defense, and aerospace. Workers can be exposed by inhalation to these NPs, for instance, through welding fumes or aerosolized propellant combustion residues. Several clinical and epidemiological studies have reported that inhalation of Al<sub>2</sub>O<sub>3</sub> NPs could trigger aluminosis, inflammation in the lung parenchyma, respiratory symptoms such as cough or shortness of breath, and probably long-term pulmonary fibrosis. The present review is a critical update of the current knowledge on underlying toxicological, molecular, and cellular mechanisms induced by exposure to Al<sub>2</sub>O<sub>3</sub> NPs in the lungs. A major part of animal studies also points out inflammatory cells and secreted biomarkers in broncho-alveolar lavage fluid (BALF) and blood serum, while in vitro studies on lung cells indicate contradictory results regarding the toxicity of these NPs. |
| first_indexed | 2024-03-09T20:37:35Z |
| format | Article |
| id | doaj.art-127a4a17d3f1446abe744bbff2ec50ad |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:37:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-127a4a17d3f1446abe744bbff2ec50ad2023-11-23T23:06:46ZengMDPI AGBiomedicines2227-90592022-10-011010266410.3390/biomedicines10102664Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the LungsSamir Dekali0Alexandra Bourgois1Sabine François2French Armed Forces Biomedical Research Institute (IRBA), Department of Biological Radiation Effects/Unit of Emerging Technological Risks, 1 Place du Général Valérie André, BP 73, CEDEX, 91223 Brétigny-sur-Orge, FranceFrench Armed Forces Biomedical Research Institute (IRBA), Department of Biological Radiation Effects/Radiobiology Unit, 1 Place du Général Valérie André, BP 73, CEDEX, 91223 Brétigny-sur-Orge, FranceFrench Armed Forces Biomedical Research Institute (IRBA), Department of Biological Radiation Effects/Radiobiology Unit, 1 Place du Général Valérie André, BP 73, CEDEX, 91223 Brétigny-sur-Orge, FranceAlumina nanoparticles (Al<sub>2</sub>O<sub>3</sub> NPs) can be released in occupational environments in different contexts such as industry, defense, and aerospace. Workers can be exposed by inhalation to these NPs, for instance, through welding fumes or aerosolized propellant combustion residues. Several clinical and epidemiological studies have reported that inhalation of Al<sub>2</sub>O<sub>3</sub> NPs could trigger aluminosis, inflammation in the lung parenchyma, respiratory symptoms such as cough or shortness of breath, and probably long-term pulmonary fibrosis. The present review is a critical update of the current knowledge on underlying toxicological, molecular, and cellular mechanisms induced by exposure to Al<sub>2</sub>O<sub>3</sub> NPs in the lungs. A major part of animal studies also points out inflammatory cells and secreted biomarkers in broncho-alveolar lavage fluid (BALF) and blood serum, while in vitro studies on lung cells indicate contradictory results regarding the toxicity of these NPs.https://www.mdpi.com/2227-9059/10/10/2664alumina nanoparticlesinflammationfibrosistoxicitylungbroncho-alveolar fluid |
| spellingShingle | Samir Dekali Alexandra Bourgois Sabine François Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs Biomedicines alumina nanoparticles inflammation fibrosis toxicity lung broncho-alveolar fluid |
| title | Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs |
| title_full | Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs |
| title_fullStr | Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs |
| title_full_unstemmed | Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs |
| title_short | Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs |
| title_sort | critical review on toxicological mechanisms triggered by inhalation of alumina nanoparticles on to the lungs |
| topic | alumina nanoparticles inflammation fibrosis toxicity lung broncho-alveolar fluid |
| url | https://www.mdpi.com/2227-9059/10/10/2664 |
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