Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis
Background: Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme ( ACE ) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320314539828 |
| Summary: | Background: Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme ( ACE ) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysis. Methods: PubMed and EMBASE were searched to identify case-control studies investigating the associations of ACE I/D polymorphism with risk of DPN. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between ACE I/D polymorphism and risk of DPN. Results: A total of seven case-control studies including 1316 cases and 1617 controls were included. ACE I/D polymorphism was associated with a significantly increased risk of DPN (OR=1.46, 95%CI 1.11–1.92, p =0.006, I 2 =48%). This result remained statistically significant when the adjusted ORs were combined (OR=1.84, 95%CI 1.14–2.99, p =0.01, I 2 =53%). In the subgroup of ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.32, 95%CI 1.10–1.59, p =0.003, I 2 =43%). Conclusions: Our meta-analysis confirmed that ACE I/D polymorphism was associated with the risk of DPN. |
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| ISSN: | 1470-3203 1752-8976 |