Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis
Background: Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme ( ACE ) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320314539828 |
| _version_ | 1797285039414706176 |
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| author | Yao Li Nanwei Tong |
| author_facet | Yao Li Nanwei Tong |
| author_sort | Yao Li |
| collection | DOAJ |
| description | Background: Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme ( ACE ) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysis. Methods: PubMed and EMBASE were searched to identify case-control studies investigating the associations of ACE I/D polymorphism with risk of DPN. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between ACE I/D polymorphism and risk of DPN. Results: A total of seven case-control studies including 1316 cases and 1617 controls were included. ACE I/D polymorphism was associated with a significantly increased risk of DPN (OR=1.46, 95%CI 1.11–1.92, p =0.006, I 2 =48%). This result remained statistically significant when the adjusted ORs were combined (OR=1.84, 95%CI 1.14–2.99, p =0.01, I 2 =53%). In the subgroup of ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.32, 95%CI 1.10–1.59, p =0.003, I 2 =43%). Conclusions: Our meta-analysis confirmed that ACE I/D polymorphism was associated with the risk of DPN. |
| first_indexed | 2024-03-07T17:57:25Z |
| format | Article |
| id | doaj.art-127b02a12978433e8b8aab08c7cc3cb4 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:57:25Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-127b02a12978433e8b8aab08c7cc3cb42024-03-02T11:47:40ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320314539828Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysisYao LiNanwei TongBackground: Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme ( ACE ) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysis. Methods: PubMed and EMBASE were searched to identify case-control studies investigating the associations of ACE I/D polymorphism with risk of DPN. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between ACE I/D polymorphism and risk of DPN. Results: A total of seven case-control studies including 1316 cases and 1617 controls were included. ACE I/D polymorphism was associated with a significantly increased risk of DPN (OR=1.46, 95%CI 1.11–1.92, p =0.006, I 2 =48%). This result remained statistically significant when the adjusted ORs were combined (OR=1.84, 95%CI 1.14–2.99, p =0.01, I 2 =53%). In the subgroup of ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.32, 95%CI 1.10–1.59, p =0.003, I 2 =43%). Conclusions: Our meta-analysis confirmed that ACE I/D polymorphism was associated with the risk of DPN.https://doi.org/10.1177/1470320314539828 |
| spellingShingle | Yao Li Nanwei Tong Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis |
| title_full | Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis |
| title_fullStr | Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis |
| title_full_unstemmed | Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis |
| title_short | Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis |
| title_sort | angiotensin converting enzyme i d polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus a meta analysis |
| url | https://doi.org/10.1177/1470320314539828 |
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