Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing
The initial discovery of killer toxin-secreting brewery strains of Saccharomyces cerevisiae (S. cerevisiae) in the mid-sixties of the last century marked the beginning of intensive research in the yeast virology field. So far, four different S. cerevisiae killer toxins (K28, K1, K2, and Klus), encod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/9/10/333 |
| _version_ | 1798002541387055104 |
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| author | Björn Becker Manfred J. Schmitt |
| author_facet | Björn Becker Manfred J. Schmitt |
| author_sort | Björn Becker |
| collection | DOAJ |
| description | The initial discovery of killer toxin-secreting brewery strains of Saccharomyces cerevisiae (S. cerevisiae) in the mid-sixties of the last century marked the beginning of intensive research in the yeast virology field. So far, four different S. cerevisiae killer toxins (K28, K1, K2, and Klus), encoded by cytoplasmic inherited double-stranded RNA viruses (dsRNA) of the Totiviridae family, have been identified. Among these, K28 represents the unique example of a yeast viral killer toxin that enters a sensitive cell by receptor-mediated endocytosis to reach its intracellular target(s). This review summarizes and discusses the most recent advances and current knowledge on yeast killer toxin K28, with special emphasis on its endocytosis and intracellular trafficking, pointing towards future directions and open questions in this still timely and fascinating field of killer yeast research. |
| first_indexed | 2024-04-11T11:53:46Z |
| format | Article |
| id | doaj.art-127bf311b8f243d2a92ed99aa9bd698d |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T11:53:46Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-127bf311b8f243d2a92ed99aa9bd698d2022-12-22T04:25:13ZengMDPI AGToxins2072-66512017-10-0191033310.3390/toxins9100333toxins9100333Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and KillingBjörn Becker0Manfred J. Schmitt1Molecular and Cell Biology, Department of Biosciences and Center of Human and Molecular Biology (ZHMB), Saarland University, D-66123 Saarbrücken, GermanyMolecular and Cell Biology, Department of Biosciences and Center of Human and Molecular Biology (ZHMB), Saarland University, D-66123 Saarbrücken, GermanyThe initial discovery of killer toxin-secreting brewery strains of Saccharomyces cerevisiae (S. cerevisiae) in the mid-sixties of the last century marked the beginning of intensive research in the yeast virology field. So far, four different S. cerevisiae killer toxins (K28, K1, K2, and Klus), encoded by cytoplasmic inherited double-stranded RNA viruses (dsRNA) of the Totiviridae family, have been identified. Among these, K28 represents the unique example of a yeast viral killer toxin that enters a sensitive cell by receptor-mediated endocytosis to reach its intracellular target(s). This review summarizes and discusses the most recent advances and current knowledge on yeast killer toxin K28, with special emphasis on its endocytosis and intracellular trafficking, pointing towards future directions and open questions in this still timely and fascinating field of killer yeast research.https://www.mdpi.com/2072-6651/9/10/333K28killer toxinS. cerevisiaeA/B toxincell wall receptorH/KDEL receptorretrograde protein transportretrotranslocationcell cycle arresttoxin immunity |
| spellingShingle | Björn Becker Manfred J. Schmitt Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing Toxins K28 killer toxin S. cerevisiae A/B toxin cell wall receptor H/KDEL receptor retrograde protein transport retrotranslocation cell cycle arrest toxin immunity |
| title | Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing |
| title_full | Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing |
| title_fullStr | Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing |
| title_full_unstemmed | Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing |
| title_short | Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing |
| title_sort | yeast killer toxin k28 biology and unique strategy of host cell intoxication and killing |
| topic | K28 killer toxin S. cerevisiae A/B toxin cell wall receptor H/KDEL receptor retrograde protein transport retrotranslocation cell cycle arrest toxin immunity |
| url | https://www.mdpi.com/2072-6651/9/10/333 |
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