Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation
Imuno TF<sup>®</sup> is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems and historically is linked to the immune system regulation. In this study, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/5/665 |
| _version_ | 1797535681241677824 |
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| author | Hudson Polonini Any Elisa de Souza Schmidt Gonçalves Eli Dijkers Anderson de Oliveira Ferreira |
| author_facet | Hudson Polonini Any Elisa de Souza Schmidt Gonçalves Eli Dijkers Anderson de Oliveira Ferreira |
| author_sort | Hudson Polonini |
| collection | DOAJ |
| description | Imuno TF<sup>®</sup> is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems and historically is linked to the immune system regulation. In this study, we demonstrate for the first time its proteomic analysis, nutritional composition, and safety profile in terms of mutagenic potential and acute oral dose (LD<sub>50</sub>). The obtained analysis indicated the product is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. The chemical composition showed low fat and low sugar content, saturated fatty acids-free, and the presence of 10 vitamins and 11 minerals. No mutagenic effect was observed, and the LD<sub>50</sub> was 5000 mg kg<sup>−1</sup> body weight. This accounts for a safe product to be used by the oral route, with potential benefits for the immune system. |
| first_indexed | 2024-03-10T11:48:49Z |
| format | Article |
| id | doaj.art-127c50e77e3949a495409ac1b59afdc8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:48:49Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-127c50e77e3949a495409ac1b59afdc82023-11-21T17:51:38ZengMDPI AGBiomolecules2218-273X2021-04-0111566510.3390/biom11050665Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System RegulationHudson Polonini0Any Elisa de Souza Schmidt Gonçalves1Eli Dijkers2Anderson de Oliveira Ferreira3Fagron B.V., Lichtenauerlaan 182, 3062 ME, Rotterdam, The NetherlandsInfinity Pharma Brasil, Av. Pierre Simon de Laplace, 751 Techno Park, Campinas, SP 13069-320, BrazilFagron B.V., Lichtenauerlaan 182, 3062 ME, Rotterdam, The NetherlandsFagron B.V., Lichtenauerlaan 182, 3062 ME, Rotterdam, The NetherlandsImuno TF<sup>®</sup> is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems and historically is linked to the immune system regulation. In this study, we demonstrate for the first time its proteomic analysis, nutritional composition, and safety profile in terms of mutagenic potential and acute oral dose (LD<sub>50</sub>). The obtained analysis indicated the product is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. The chemical composition showed low fat and low sugar content, saturated fatty acids-free, and the presence of 10 vitamins and 11 minerals. No mutagenic effect was observed, and the LD<sub>50</sub> was 5000 mg kg<sup>−1</sup> body weight. This accounts for a safe product to be used by the oral route, with potential benefits for the immune system.https://www.mdpi.com/2218-273X/11/5/665transfer factorImuno TFsafety profilecharacterizationpeptidesproteomics |
| spellingShingle | Hudson Polonini Any Elisa de Souza Schmidt Gonçalves Eli Dijkers Anderson de Oliveira Ferreira Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation Biomolecules transfer factor Imuno TF safety profile characterization peptides proteomics |
| title | Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation |
| title_full | Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation |
| title_fullStr | Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation |
| title_full_unstemmed | Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation |
| title_short | Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation |
| title_sort | characterization and safety profile of transfer factors peptides a nutritional supplement for immune system regulation |
| topic | transfer factor Imuno TF safety profile characterization peptides proteomics |
| url | https://www.mdpi.com/2218-273X/11/5/665 |
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