Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma

Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL). B-cell NHLs rely on Bruton’s tyrosine kinase (BTK) mediated B-cell receptor signaling for survival and disease progression. However, they are often resistant to BTK inhibitors or soon acquire resistance after drug e...

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Bibliographic Details
Main Authors: Fouad Choueiry, Satishkumar Singh, Anuvrat Sircar, Georgios Laliotis, Xiaowei Sun, Evangelia Chavdoula, Shiqi Zhang, JoBeth Helmig-Mason, Amber Hart, Narendranath Epperla, Philip Tsichlis, Robert Baiocchi, Lapo Alinari, Jiangjiang Zhu, Lalit Sehgal
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
DLBCL
lymphoma
transcriptomic
metabolomics
drug resistance
ibrutinib
Online Access:https://www.mdpi.com/2072-6694/13/9/2146

Internet

https://www.mdpi.com/2072-6694/13/9/2146

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