Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population
Objective: To verify possible associations between polymorphisms of glutathione S-transferase Mu (GSTM1), glutathione S-transferase θ (GSTT1) and glutathione S-transferase Pi (GSTP1) genes and susceptibility to lung cancer. Methods: A total of 106 lung cancer patients and 116 controls were enrolled...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-12-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115301155 |
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| author | Mir Muhammad Nasir Uddin Maizbha Uddin Ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam Muhammad Shahdaat Bin Sayeed Yearul Kabir Abul Hasnat |
| author_facet | Mir Muhammad Nasir Uddin Maizbha Uddin Ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam Muhammad Shahdaat Bin Sayeed Yearul Kabir Abul Hasnat |
| author_sort | Mir Muhammad Nasir Uddin |
| collection | DOAJ |
| description | Objective: To verify possible associations between polymorphisms of glutathione S-transferase Mu (GSTM1), glutathione S-transferase θ (GSTT1) and glutathione S-transferase Pi (GSTP1) genes and susceptibility to lung cancer.
Methods: A total of 106 lung cancer patients and 116 controls were enrolled in a case-control study. The GSTM1 and GSTT1 were analyzed using PCR while GSTP1 was analyzed using PCR-restriction fragment length polymorphism. Risk of lung cancer was estimated as odds ratio at 95% confidence interval using unconditional logistic regression models adjusting for age, sex, and tobacco use.
Results: GSTM1 null and GSTT1 null genotypes did not show a significant risk for developing lung cancer. A significantly elevated lung cancer risk was associated with GSTP1 heterozygous, mutant and combined heterozygous+mutant variants of rs1695. When classified by tobacco consumption status, no association with risk of lung cancer was found in case of tobacco smokers and nonsmokers carrying null and present genotypes of GSTM1 and GSTT1. There is a three-fold (approximately) increase in the risk of lung cancer in case of both heterozygous (AG) and heterozygous+mutant homozygous (AG+GG) genotypes whereas there is an eight-fold increase in risk of lung cancer in cases of GG with respect to AA genotype in smokers.
Conclusions: Carrying the GSTM1 and GSTT1 null genotype is not a risk factor for lung cancer and GSTP1Ile105Val is associated with elevated risk of lung cancer. |
| first_indexed | 2024-12-19T07:44:36Z |
| format | Article |
| id | doaj.art-127e7e31a38f4c538b308ff5b2df4873 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-19T07:44:36Z |
| publishDate | 2014-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-127e7e31a38f4c538b308ff5b2df48732022-12-21T20:30:23ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-12-0141298298910.12980/APJTB.4.2014APJTB-2014-0476Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi populationMir Muhammad Nasir Uddin0Maizbha Uddin Ahmed1Mohammad Safiqul Islam2Mohammad Siddiqul Islam3Muhammad Shahdaat Bin Sayeed4Yearul Kabir5Abul Hasnat6Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Dhaka-1000, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Dhaka-1000, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Dhaka-1000, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Dhaka-1000, BangladeshDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, BangladeshDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Dhaka-1000, BangladeshObjective: To verify possible associations between polymorphisms of glutathione S-transferase Mu (GSTM1), glutathione S-transferase θ (GSTT1) and glutathione S-transferase Pi (GSTP1) genes and susceptibility to lung cancer. Methods: A total of 106 lung cancer patients and 116 controls were enrolled in a case-control study. The GSTM1 and GSTT1 were analyzed using PCR while GSTP1 was analyzed using PCR-restriction fragment length polymorphism. Risk of lung cancer was estimated as odds ratio at 95% confidence interval using unconditional logistic regression models adjusting for age, sex, and tobacco use. Results: GSTM1 null and GSTT1 null genotypes did not show a significant risk for developing lung cancer. A significantly elevated lung cancer risk was associated with GSTP1 heterozygous, mutant and combined heterozygous+mutant variants of rs1695. When classified by tobacco consumption status, no association with risk of lung cancer was found in case of tobacco smokers and nonsmokers carrying null and present genotypes of GSTM1 and GSTT1. There is a three-fold (approximately) increase in the risk of lung cancer in case of both heterozygous (AG) and heterozygous+mutant homozygous (AG+GG) genotypes whereas there is an eight-fold increase in risk of lung cancer in cases of GG with respect to AA genotype in smokers. Conclusions: Carrying the GSTM1 and GSTT1 null genotype is not a risk factor for lung cancer and GSTP1Ile105Val is associated with elevated risk of lung cancer.http://www.sciencedirect.com/science/article/pii/S2221169115301155Lung cancerGlutathione S-transferaseGenetic polymorphismSmoking |
| spellingShingle | Mir Muhammad Nasir Uddin Maizbha Uddin Ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam Muhammad Shahdaat Bin Sayeed Yearul Kabir Abul Hasnat Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population Asian Pacific Journal of Tropical Biomedicine Lung cancer Glutathione S-transferase Genetic polymorphism Smoking |
| title | Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population |
| title_full | Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population |
| title_fullStr | Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population |
| title_full_unstemmed | Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population |
| title_short | Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population |
| title_sort | genetic polymorphisms of gstm1 gstp1 and gstt1 genes and lung cancer susceptibility in the bangladeshi population |
| topic | Lung cancer Glutathione S-transferase Genetic polymorphism Smoking |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115301155 |
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