Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children
Background: The World Health Organization recommends use of a single yellow fever (YF) vaccine dose for life and fractional doses in outbreaks when there are limited vaccine stocks. In endemic regions, this vaccine is given as part of routine infant immunization programs around 9 months of age. Ther...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-08-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | http://dx.doi.org/10.1080/14760584.2019.1640118 |
| _version_ | 1827813205807726592 |
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| author | Olubukola T. Idoko Nuredin Mohammed Patrick Ansah Abraham Hodgson Milagritos D. Tapia Samba O. Sow Paanchali R. Chowdhury Matthias Niedrig Elmar Saathoff Beate Kampmann |
| author_facet | Olubukola T. Idoko Nuredin Mohammed Patrick Ansah Abraham Hodgson Milagritos D. Tapia Samba O. Sow Paanchali R. Chowdhury Matthias Niedrig Elmar Saathoff Beate Kampmann |
| author_sort | Olubukola T. Idoko |
| collection | DOAJ |
| description | Background: The World Health Organization recommends use of a single yellow fever (YF) vaccine dose for life and fractional doses in outbreaks when there are limited vaccine stocks. In endemic regions, this vaccine is given as part of routine infant immunization programs around 9 months of age. There is a need to better understand immune responses when vaccinating infants particularly in contexts where the child may be malnourished. Methods: Data from 393 Malian and Ghanaian infants who concomitantly received measles and YF vaccines at 9 to 11 months of age were retrospectively analyzed. Response to YF vaccine was examined for association with nutritional status at time of vaccination, sex, age, pre-vaccination titers and season of vaccination. Results: Neutralizing antibodies following vaccination were unaffected by season of vaccination, sex, pre-vaccination titers or nutritional status, though there was a trend to higher titers in males and children with higher height for age z-scores. Seroconversion rates differed significantly between countries (63.5 in Ghana vs. 91.0% in Mali). Conclusion: Longitudinal, prospective studies are needed to optimize the use of YF vaccine in infants in endemic settings. There may be a need for booster vaccinations and to compare various vaccine preparations to optimize the use of available vaccines. |
| first_indexed | 2024-03-11T23:28:32Z |
| format | Article |
| id | doaj.art-127f5903557c4a9ebc4340dd8b6d5b3c |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:28:32Z |
| publishDate | 2019-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-127f5903557c4a9ebc4340dd8b6d5b3c2023-09-20T10:18:04ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952019-08-0118886787510.1080/14760584.2019.16401181640118Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian childrenOlubukola T. Idoko0Nuredin Mohammed1Patrick Ansah2Abraham Hodgson3Milagritos D. Tapia4Samba O. Sow5Paanchali R. Chowdhury6Matthias Niedrig7Elmar Saathoff8Beate Kampmann9Medical Research Council Unit The Gambia at London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at London School of Hygiene and Tropical MedicineGhana Health ServiceGhana Health ServiceUniversity of MarylandUniversity of MarylandRobert Koch InstituteRobert Koch InstituteUniversity HospitalMedical Research Council Unit The Gambia at London School of Hygiene and Tropical MedicineBackground: The World Health Organization recommends use of a single yellow fever (YF) vaccine dose for life and fractional doses in outbreaks when there are limited vaccine stocks. In endemic regions, this vaccine is given as part of routine infant immunization programs around 9 months of age. There is a need to better understand immune responses when vaccinating infants particularly in contexts where the child may be malnourished. Methods: Data from 393 Malian and Ghanaian infants who concomitantly received measles and YF vaccines at 9 to 11 months of age were retrospectively analyzed. Response to YF vaccine was examined for association with nutritional status at time of vaccination, sex, age, pre-vaccination titers and season of vaccination. Results: Neutralizing antibodies following vaccination were unaffected by season of vaccination, sex, pre-vaccination titers or nutritional status, though there was a trend to higher titers in males and children with higher height for age z-scores. Seroconversion rates differed significantly between countries (63.5 in Ghana vs. 91.0% in Mali). Conclusion: Longitudinal, prospective studies are needed to optimize the use of YF vaccine in infants in endemic settings. There may be a need for booster vaccinations and to compare various vaccine preparations to optimize the use of available vaccines.http://dx.doi.org/10.1080/14760584.2019.1640118neutralizing antibodyyellow fever (yf)vaccineafricaninfant |
| spellingShingle | Olubukola T. Idoko Nuredin Mohammed Patrick Ansah Abraham Hodgson Milagritos D. Tapia Samba O. Sow Paanchali R. Chowdhury Matthias Niedrig Elmar Saathoff Beate Kampmann Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children Expert Review of Vaccines neutralizing antibody yellow fever (yf) vaccine african infant |
| title | Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children |
| title_full | Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children |
| title_fullStr | Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children |
| title_full_unstemmed | Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children |
| title_short | Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children |
| title_sort | antibody responses to yellow fever vaccine in 9 to 11 month old malian and ghanaian children |
| topic | neutralizing antibody yellow fever (yf) vaccine african infant |
| url | http://dx.doi.org/10.1080/14760584.2019.1640118 |
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