Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy
The drug efficacy evaluation of tumor-selective photosensitive substances was expected to be enabled by imaging the fluorescence intensity in the tumor area. However, fluorescence observation is difficult during treatments that are performed during gastrointestinal endoscopy because of the challenge...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/24/5/1487 |
| _version_ | 1797263857605935104 |
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| author | Toshihiro Takamatsu Hideki Tanaka Tomonori Yano |
| author_facet | Toshihiro Takamatsu Hideki Tanaka Tomonori Yano |
| author_sort | Toshihiro Takamatsu |
| collection | DOAJ |
| description | The drug efficacy evaluation of tumor-selective photosensitive substances was expected to be enabled by imaging the fluorescence intensity in the tumor area. However, fluorescence observation is difficult during treatments that are performed during gastrointestinal endoscopy because of the challenges associated with including the fluorescence filter in the camera part. To address this issue, this study developed a device that integrates a narrow camera and a laser diffuser to enable fluorescence imaging through a forceps port. This device was employed to demonstrate that a laser diffuser with an NIR fluorescence imaging sensor could be delivered through a 3.2 mm diameter port. In addition, fluorescence images of Cetuximab-IR700 were successfully observed in two mice, and the fluorescence intensity confirmed that the fluorescence decayed within 330 s. This device is expected to have practical application as a tool to identify the optimal irradiation dose for tumor-selective photosensitive substances under endoscopy. |
| first_indexed | 2024-04-25T00:19:40Z |
| format | Article |
| id | doaj.art-1280da3b0ecc4a7ab2ee710f838cbdab |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-25T00:19:40Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-1280da3b0ecc4a7ab2ee710f838cbdab2024-03-12T16:54:57ZengMDPI AGSensors1424-82202024-02-01245148710.3390/s24051487Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under EndoscopyToshihiro Takamatsu0Hideki Tanaka1Tomonori Yano2Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa 277-8577, Chiba, JapanDepartment of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa 277-8577, Chiba, JapanExploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa 277-8577, Chiba, JapanThe drug efficacy evaluation of tumor-selective photosensitive substances was expected to be enabled by imaging the fluorescence intensity in the tumor area. However, fluorescence observation is difficult during treatments that are performed during gastrointestinal endoscopy because of the challenges associated with including the fluorescence filter in the camera part. To address this issue, this study developed a device that integrates a narrow camera and a laser diffuser to enable fluorescence imaging through a forceps port. This device was employed to demonstrate that a laser diffuser with an NIR fluorescence imaging sensor could be delivered through a 3.2 mm diameter port. In addition, fluorescence images of Cetuximab-IR700 were successfully observed in two mice, and the fluorescence intensity confirmed that the fluorescence decayed within 330 s. This device is expected to have practical application as a tool to identify the optimal irradiation dose for tumor-selective photosensitive substances under endoscopy.https://www.mdpi.com/1424-8220/24/5/1487NIR fluorescence imagingphotosensitive substanceendoscopein vivoforceps port |
| spellingShingle | Toshihiro Takamatsu Hideki Tanaka Tomonori Yano Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy Sensors NIR fluorescence imaging photosensitive substance endoscope in vivo forceps port |
| title | Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy |
| title_full | Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy |
| title_fullStr | Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy |
| title_full_unstemmed | Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy |
| title_short | Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy |
| title_sort | near infrared fluorescence imaging sensor with laser diffuser for visualizing photoimmunotherapy effects under endoscopy |
| topic | NIR fluorescence imaging photosensitive substance endoscope in vivo forceps port |
| url | https://www.mdpi.com/1424-8220/24/5/1487 |
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