Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice

Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice

Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) are the central classical checkpoint inhibitory (C...

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Main Authors: Nycolas Willian Preite, Bruno Montanari Borges, Valéria de Lima Kaminski, Marina Caçador Ayupe, Leonardo Mandu Gonçalves, Bianca Vieira dos Santos, Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Caio Loureiro Salgado, Sandra Marcia Muxel, Otavio Cabral-Marques, Denise Morais da Fonseca, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
pulmonary paracoccidioidomycosis
PD-1 and CTLA-4 blockade
protective effect
fungal clearance
reduced dissemination
improved immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347318/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347318/full

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