DNA damage response and Autophagy: a meaningful partnership
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00204/full |
| _version_ | 1818025063285260288 |
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| author | ARISTIDES G ELIOPOULOS ARISTIDES G ELIOPOULOS Sophia Havaki Vassilis G Gorgoulis Vassilis G Gorgoulis Vassilis G Gorgoulis |
| author_facet | ARISTIDES G ELIOPOULOS ARISTIDES G ELIOPOULOS Sophia Havaki Vassilis G Gorgoulis Vassilis G Gorgoulis Vassilis G Gorgoulis |
| author_sort | ARISTIDES G ELIOPOULOS |
| collection | DOAJ |
| description | Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the mechanisms by which autophagy and DDR are intertwined provides novel insight into the pathobiology of conditions associated with accumulation of DNA damage, including cancer and aging, and novel concepts for the development of improved therapeutic strategies against these pathologies. |
| first_indexed | 2024-12-10T04:10:09Z |
| format | Article |
| id | doaj.art-1283c63e5cec4e7eb99c2818830d27c9 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T04:10:09Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-1283c63e5cec4e7eb99c2818830d27c92022-12-22T02:02:45ZengFrontiers Media S.A.Frontiers in Genetics1664-80212016-11-01710.3389/fgene.2016.00204236822DNA damage response and Autophagy: a meaningful partnershipARISTIDES G ELIOPOULOS0ARISTIDES G ELIOPOULOS1Sophia Havaki2Vassilis G Gorgoulis3Vassilis G Gorgoulis4Vassilis G Gorgoulis5UNIVERSITY OF CRETEFoundation for Research and Technology HellasNational and Kapodistrian University of AthensNational and Kapodistrian University of AthensUniversity of ManchesterBiomedical Research Foundation of the Academy of AthensAutophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the mechanisms by which autophagy and DDR are intertwined provides novel insight into the pathobiology of conditions associated with accumulation of DNA damage, including cancer and aging, and novel concepts for the development of improved therapeutic strategies against these pathologies.http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00204/fullAutophagyCell DeathDNA DamageInflammationevolutionsenescence |
| spellingShingle | ARISTIDES G ELIOPOULOS ARISTIDES G ELIOPOULOS Sophia Havaki Vassilis G Gorgoulis Vassilis G Gorgoulis Vassilis G Gorgoulis DNA damage response and Autophagy: a meaningful partnership Frontiers in Genetics Autophagy Cell Death DNA Damage Inflammation evolution senescence |
| title | DNA damage response and Autophagy: a meaningful partnership |
| title_full | DNA damage response and Autophagy: a meaningful partnership |
| title_fullStr | DNA damage response and Autophagy: a meaningful partnership |
| title_full_unstemmed | DNA damage response and Autophagy: a meaningful partnership |
| title_short | DNA damage response and Autophagy: a meaningful partnership |
| title_sort | dna damage response and autophagy a meaningful partnership |
| topic | Autophagy Cell Death DNA Damage Inflammation evolution senescence |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00204/full |
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