A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales <named-content content-type="genus-species">Mucor circinelloides</named-content>

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales <named-content content-type="genus-species">Mucor circinelloides</named-content>

ABSTRACT Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales. Calcineurin is a conserved virulence factor in many pathogenic fungi, and calcineurin i...

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Bibliographic Details
Main Authors: Sandeep Vellanki, R. Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
Mucor
mucormycosis
amino acid permease
calcineurin
dimorphism
drug resistance mechanisms
Online Access:https://journals.asm.org/doi/10.1128/mBio.02949-19

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