Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources
Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activitie...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/18/5582 |
| _version_ | 1797517984315473920 |
|---|---|
| author | Alfred Ngenge Tamfu Selcuk Kucukaydin Balakyz Yeskaliyeva Mehmet Ozturk Rodica Mihaela Dinica |
| author_facet | Alfred Ngenge Tamfu Selcuk Kucukaydin Balakyz Yeskaliyeva Mehmet Ozturk Rodica Mihaela Dinica |
| author_sort | Alfred Ngenge Tamfu |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease. |
| first_indexed | 2024-03-10T07:23:48Z |
| format | Article |
| id | doaj.art-1284b3be9b044aa3a5deeb33d4ccf13c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:23:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1284b3be9b044aa3a5deeb33d4ccf13c2023-11-22T14:25:19ZengMDPI AGMolecules1420-30492021-09-012618558210.3390/molecules26185582Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural SourcesAlfred Ngenge Tamfu0Selcuk Kucukaydin1Balakyz Yeskaliyeva2Mehmet Ozturk3Rodica Mihaela Dinica4School of Chemical Engineering and Mineral Industries, University of Ngaoundere, 454 Ngaoundere, CameroonDepartment of Medical Services and Techniques, Koycegiz Vocational School of Health Services, Mugla Sitki Kocman University, Mugla 48800, TurkeyDepartment of Chemistry, Mugla Sitki Kocman University, Mugla 48000, TurkeyDepartment of Chemistry, Mugla Sitki Kocman University, Mugla 48000, TurkeyDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, Dunarea de Jos University, 47 Domneasca Str., 800008 Galati, RomaniaAlzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.https://www.mdpi.com/1420-3049/26/18/5582Alzheimer’s diseasecholinesterase inhibitorsterpenoidsphenolic compoundscoumarins |
| spellingShingle | Alfred Ngenge Tamfu Selcuk Kucukaydin Balakyz Yeskaliyeva Mehmet Ozturk Rodica Mihaela Dinica Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources Molecules Alzheimer’s disease cholinesterase inhibitors terpenoids phenolic compounds coumarins |
| title | Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources |
| title_full | Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources |
| title_fullStr | Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources |
| title_full_unstemmed | Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources |
| title_short | Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources |
| title_sort | non alkaloid cholinesterase inhibitory compounds from natural sources |
| topic | Alzheimer’s disease cholinesterase inhibitors terpenoids phenolic compounds coumarins |
| url | https://www.mdpi.com/1420-3049/26/18/5582 |
| work_keys_str_mv | AT alfredngengetamfu nonalkaloidcholinesteraseinhibitorycompoundsfromnaturalsources AT selcukkucukaydin nonalkaloidcholinesteraseinhibitorycompoundsfromnaturalsources AT balakyzyeskaliyeva nonalkaloidcholinesteraseinhibitorycompoundsfromnaturalsources AT mehmetozturk nonalkaloidcholinesteraseinhibitorycompoundsfromnaturalsources AT rodicamihaeladinica nonalkaloidcholinesteraseinhibitorycompoundsfromnaturalsources |