Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Abstract Background In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states. Extensive literature reviews indicate the diverse biological effects of benzimidazole and piperazine derivatives, notably their impact on the cent...

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Bibliographic Details
Main Authors: Bhavna Sunil Mahajan, Laxman A. Kawale, Vandana S. Nade, Supriya Unavane, Lida Sajimon, Prajakta Kapadnis
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Benzimidazole derivatives
Piperazines
Docking
Hole board test
Elevated Plus Maze (EPM) test
Anti-anxiety agents
Online Access:https://doi.org/10.1186/s43094-024-00626-0

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