Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma
The paper presents a study on the changes in cognitive functioning in patients undergoing chemotherapy with diagnosed multiple myeloma (MM). The aim of the study was to answer the following two main research questions: Does the treatment stage differentiate the functioning of cognitive processes in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/9/1166 |
| _version_ | 1797520020664745984 |
|---|---|
| author | Magdalena Bury-Kamińska Aneta Szudy-Szczyrek Aleksandra Nowaczyńska Olga Jankowska-Łęcka Marek Hus Klaudia Kot |
| author_facet | Magdalena Bury-Kamińska Aneta Szudy-Szczyrek Aleksandra Nowaczyńska Olga Jankowska-Łęcka Marek Hus Klaudia Kot |
| author_sort | Magdalena Bury-Kamińska |
| collection | DOAJ |
| description | The paper presents a study on the changes in cognitive functioning in patients undergoing chemotherapy with diagnosed multiple myeloma (MM). The aim of the study was to answer the following two main research questions: Does the treatment stage differentiate the functioning of cognitive processes in patients with diagnosed MM and to what extent? Is it possible to treat biological factors (TNF-α, IL-6, IL-10, and BDNF) as predictors of patients’ cognitive functioning? The patients were examined twice, before the treatment and after 4–6 cycles of chemotherapy. Selected neuropsychological research methods as well as experimental and clinical trials were employed to diagnose the patients’ general cognitive state, attention, memory, and executive functions. The level of biological factors was assessed with the ELISA test. The results show that the patients’ cognitive functioning was worse before the treatment than during the cytostatic therapy. It was also possible to predict the cognitive state of patients suffering from multiple myeloma based on a selected biological parameter (neurotrophin BDNF). |
| first_indexed | 2024-03-10T07:50:55Z |
| format | Article |
| id | doaj.art-1286abf37ff142e0a9dff887e3dba64c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T07:50:55Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1286abf37ff142e0a9dff887e3dba64c2023-11-22T12:14:04ZengMDPI AGBrain Sciences2076-34252021-09-01119116610.3390/brainsci11091166Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple MyelomaMagdalena Bury-Kamińska0Aneta Szudy-Szczyrek1Aleksandra Nowaczyńska2Olga Jankowska-Łęcka3Marek Hus4Klaudia Kot5Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Maria Curie-Skłodowska University in Lublin, 45 Głęboka, 20-612 Lublin, PolandDepartment of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, 2 Karmelicka, 20-400 Lublin, PolandDepartment of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, 2 Karmelicka, 20-400 Lublin, PolandDepartment of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, 2 Karmelicka, 20-400 Lublin, PolandDepartment of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, 2 Karmelicka, 20-400 Lublin, PolandDepartment of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, 2 Karmelicka, 20-400 Lublin, PolandThe paper presents a study on the changes in cognitive functioning in patients undergoing chemotherapy with diagnosed multiple myeloma (MM). The aim of the study was to answer the following two main research questions: Does the treatment stage differentiate the functioning of cognitive processes in patients with diagnosed MM and to what extent? Is it possible to treat biological factors (TNF-α, IL-6, IL-10, and BDNF) as predictors of patients’ cognitive functioning? The patients were examined twice, before the treatment and after 4–6 cycles of chemotherapy. Selected neuropsychological research methods as well as experimental and clinical trials were employed to diagnose the patients’ general cognitive state, attention, memory, and executive functions. The level of biological factors was assessed with the ELISA test. The results show that the patients’ cognitive functioning was worse before the treatment than during the cytostatic therapy. It was also possible to predict the cognitive state of patients suffering from multiple myeloma based on a selected biological parameter (neurotrophin BDNF).https://www.mdpi.com/2076-3425/11/9/1166cancer-related cognitive dysfunctionscytokineshematooncology |
| spellingShingle | Magdalena Bury-Kamińska Aneta Szudy-Szczyrek Aleksandra Nowaczyńska Olga Jankowska-Łęcka Marek Hus Klaudia Kot Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma Brain Sciences cancer-related cognitive dysfunctions cytokines hematooncology |
| title | Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma |
| title_full | Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma |
| title_fullStr | Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma |
| title_full_unstemmed | Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma |
| title_short | Chemotherapy-Related Differences in Cognitive Functioning and Their Biological Predictors in Patients with Multiple Myeloma |
| title_sort | chemotherapy related differences in cognitive functioning and their biological predictors in patients with multiple myeloma |
| topic | cancer-related cognitive dysfunctions cytokines hematooncology |
| url | https://www.mdpi.com/2076-3425/11/9/1166 |
| work_keys_str_mv | AT magdalenaburykaminska chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma AT anetaszudyszczyrek chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma AT aleksandranowaczynska chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma AT olgajankowskałecka chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma AT marekhus chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma AT klaudiakot chemotherapyrelateddifferencesincognitivefunctioningandtheirbiologicalpredictorsinpatientswithmultiplemyeloma |