The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC
THC has been used as a promising treatment approach for neurological disorders, but the highly psychoactive effects have largely warned off many scientists from pursuing it further. We conducted an intranasal treatment using low-dose THC on 12-month-old APP/PS1 mice daily for 3 months to overcome an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4253 |
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| author | Oksana Fihurka Yuzhu Hong Jiyu Yan Breanna Brown Xiaoyang Lin Ning Shen Yanhong Wang Haohan Zhao Marcia N. Gordon David Morgan Qingyu Zhou Ping Chang Chuanhai Cao |
| author_facet | Oksana Fihurka Yuzhu Hong Jiyu Yan Breanna Brown Xiaoyang Lin Ning Shen Yanhong Wang Haohan Zhao Marcia N. Gordon David Morgan Qingyu Zhou Ping Chang Chuanhai Cao |
| author_sort | Oksana Fihurka |
| collection | DOAJ |
| description | THC has been used as a promising treatment approach for neurological disorders, but the highly psychoactive effects have largely warned off many scientists from pursuing it further. We conducted an intranasal treatment using low-dose THC on 12-month-old APP/PS1 mice daily for 3 months to overcome any potential psychoactive response induced by the systemic delivery. Our results demonstrate that the THC nasal treatment at 0.002 and 0.02 mg/kg significantly slowed the memory decline compared to that in the vehicle-treated transgenic mouse control group. An enzyme-linked immunosorbent assay showed that the Aβ1–40 and 1–42 peptides decreased in the THC-treated groups. The Western blot data indicate that long-term low-dose THC intranasal administration promoted p-tau level reduction and mitochondrial function marker redistribution. The blood biochemical parameter data demonstrate some insignificant changes in cytokine, immunoglobulin, and immune cell profiles during intranasal THC treatment. Intranasal delivery is a non-invasive and convenient method that rapidly targets therapeutics to the brain, minimizing systemic exposure to avoid unwanted adverse effects. Our study provides new insights into the role of low-dose THC intranasal treatment as a pharmacological strategy to counteract alterations in Alzheimer’s disease-related cognitive performance. |
| first_indexed | 2024-03-09T10:33:44Z |
| format | Article |
| id | doaj.art-1286ae3b99af4014a3887113b0806b15 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:33:44Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1286ae3b99af4014a3887113b0806b152023-12-01T21:03:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238425310.3390/ijms23084253The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THCOksana Fihurka0Yuzhu Hong1Jiyu Yan2Breanna Brown3Xiaoyang Lin4Ning Shen5Yanhong Wang6Haohan Zhao7Marcia N. Gordon8David Morgan9Qingyu Zhou10Ping Chang11Chuanhai Cao12Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USADepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USADepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USARhodes Pharmaceuticals L.P., Coventry, RI 02816, USADepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USATHC has been used as a promising treatment approach for neurological disorders, but the highly psychoactive effects have largely warned off many scientists from pursuing it further. We conducted an intranasal treatment using low-dose THC on 12-month-old APP/PS1 mice daily for 3 months to overcome any potential psychoactive response induced by the systemic delivery. Our results demonstrate that the THC nasal treatment at 0.002 and 0.02 mg/kg significantly slowed the memory decline compared to that in the vehicle-treated transgenic mouse control group. An enzyme-linked immunosorbent assay showed that the Aβ1–40 and 1–42 peptides decreased in the THC-treated groups. The Western blot data indicate that long-term low-dose THC intranasal administration promoted p-tau level reduction and mitochondrial function marker redistribution. The blood biochemical parameter data demonstrate some insignificant changes in cytokine, immunoglobulin, and immune cell profiles during intranasal THC treatment. Intranasal delivery is a non-invasive and convenient method that rapidly targets therapeutics to the brain, minimizing systemic exposure to avoid unwanted adverse effects. Our study provides new insights into the role of low-dose THC intranasal treatment as a pharmacological strategy to counteract alterations in Alzheimer’s disease-related cognitive performance.https://www.mdpi.com/1422-0067/23/8/4253THCAPP/PS1amyloid betap-tau |
| spellingShingle | Oksana Fihurka Yuzhu Hong Jiyu Yan Breanna Brown Xiaoyang Lin Ning Shen Yanhong Wang Haohan Zhao Marcia N. Gordon David Morgan Qingyu Zhou Ping Chang Chuanhai Cao The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC International Journal of Molecular Sciences THC APP/PS1 amyloid beta p-tau |
| title | The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC |
| title_full | The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC |
| title_fullStr | The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC |
| title_full_unstemmed | The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC |
| title_short | The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC |
| title_sort | memory benefit to aged app ps1 mice from long term intranasal treatment of low dose thc |
| topic | THC APP/PS1 amyloid beta p-tau |
| url | https://www.mdpi.com/1422-0067/23/8/4253 |
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