Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturba...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00384/full |
| _version_ | 1818422721531346944 |
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| author | Yoon S. Oh Gong D. Bae Dong J. Baek Eun-Young Park Hee-Sook Jun Hee-Sook Jun Hee-Sook Jun |
| author_facet | Yoon S. Oh Gong D. Bae Dong J. Baek Eun-Young Park Hee-Sook Jun Hee-Sook Jun Hee-Sook Jun |
| author_sort | Yoon S. Oh |
| collection | DOAJ |
| description | Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturbances in lipid metabolism regulation are associated with obesity, and they are major factors influencing the increase in the incidence of type 2 diabetes. Chronic free FA (FFA) treatment induces insulin resistance and beta-cell dysfunction; therefore, reduction of elevated plasma FFA levels might be an important therapeutic target in obesity and type 2 diabetes. Lipid signals via receptors, and intracellular mechanisms are involved in FFA-induced apoptosis. In this paper, we discuss lipid actions in beta cells, including effects on metabolic pathways and stress responses, to help further understand the molecular mechanisms of lipotoxicity-induced type 2 diabetes. |
| first_indexed | 2024-12-14T13:30:45Z |
| format | Article |
| id | doaj.art-1287f2deab6b4d8599bb5e4c7a5f76a0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T13:30:45Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1287f2deab6b4d8599bb5e4c7a5f76a02022-12-21T22:59:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-07-01910.3389/fendo.2018.00384371803Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 DiabetesYoon S. Oh0Gong D. Bae1Dong J. Baek2Eun-Young Park3Hee-Sook Jun4Hee-Sook Jun5Hee-Sook Jun6Department of Food and Nutrition, Eulji University, Seongnam, South KoreaDepartment of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, South KoreaCollege of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, South KoreaCollege of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, South KoreaDepartment of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, South KoreaGachon Institute of Pharmaceutical Science, College of Pharmacy, Gachon University, Incheon, South KoreaGachon University Gil Medical Center, Gachon Medical and Convergence Institute, Incheon, South KoreaType 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturbances in lipid metabolism regulation are associated with obesity, and they are major factors influencing the increase in the incidence of type 2 diabetes. Chronic free FA (FFA) treatment induces insulin resistance and beta-cell dysfunction; therefore, reduction of elevated plasma FFA levels might be an important therapeutic target in obesity and type 2 diabetes. Lipid signals via receptors, and intracellular mechanisms are involved in FFA-induced apoptosis. In this paper, we discuss lipid actions in beta cells, including effects on metabolic pathways and stress responses, to help further understand the molecular mechanisms of lipotoxicity-induced type 2 diabetes.https://www.frontiersin.org/article/10.3389/fendo.2018.00384/fullfatty acidbeta-celllipotoxicityinsulin secretiontype 2 diabetes |
| spellingShingle | Yoon S. Oh Gong D. Bae Dong J. Baek Eun-Young Park Hee-Sook Jun Hee-Sook Jun Hee-Sook Jun Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes Frontiers in Endocrinology fatty acid beta-cell lipotoxicity insulin secretion type 2 diabetes |
| title | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes |
| title_full | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes |
| title_fullStr | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes |
| title_full_unstemmed | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes |
| title_short | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes |
| title_sort | fatty acid induced lipotoxicity in pancreatic beta cells during development of type 2 diabetes |
| topic | fatty acid beta-cell lipotoxicity insulin secretion type 2 diabetes |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00384/full |
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