Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturba...

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Bibliographic Details
Main Authors: Yoon S. Oh, Gong D. Bae, Dong J. Baek, Eun-Young Park, Hee-Sook Jun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Endocrinology
Subjects:
fatty acid
beta-cell
lipotoxicity
insulin secretion
type 2 diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00384/full

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