Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression
CRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/CCDH1 targets SAG for ubiquitylation and d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1837582 |
| _version_ | 1797677127514980352 |
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| author | Shizhen Zhang Yi Sun |
| author_facet | Shizhen Zhang Yi Sun |
| author_sort | Shizhen Zhang |
| collection | DOAJ |
| description | CRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/CCDH1 targets SAG for ubiquitylation and degradation at G1 phase. The negative crosstalk between these two E3s ensures the orderly cell cycle progression. |
| first_indexed | 2024-03-11T22:39:30Z |
| format | Article |
| id | doaj.art-12886a56c73043fe90e2c085d2fb6482 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:30Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-12886a56c73043fe90e2c085d2fb64822023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-01-018110.1080/23723556.2020.18375821837582Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progressionShizhen Zhang0Yi Sun1Zhejiang University School of MedicineZhejiang University School of MedicineCRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/CCDH1 targets SAG for ubiquitylation and degradation at G1 phase. The negative crosstalk between these two E3s ensures the orderly cell cycle progression.http://dx.doi.org/10.1080/23723556.2020.1837582sagapc/cube2cube2scell cycle |
| spellingShingle | Shizhen Zhang Yi Sun Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression Molecular & Cellular Oncology sag apc/c ube2c ube2s cell cycle |
| title | Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression |
| title_full | Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression |
| title_fullStr | Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression |
| title_full_unstemmed | Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression |
| title_short | Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression |
| title_sort | mutual inactivation of two ring finger type e3 ubiquitin ligases during cell cycle progression |
| topic | sag apc/c ube2c ube2s cell cycle |
| url | http://dx.doi.org/10.1080/23723556.2020.1837582 |
| work_keys_str_mv | AT shizhenzhang mutualinactivationoftworingfingertypee3ubiquitinligasesduringcellcycleprogression AT yisun mutualinactivationoftworingfingertypee3ubiquitinligasesduringcellcycleprogression |