The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial
Abstract Background Polycystic Ovary Syndrome (PCOS) is known as the most common endocrine disorder of women in reproductive ages. With the increasing prevalence of PCOS in different countries, the use of herbal medicine as an alternative treatment is growing in these patients. This study aimed to e...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-020-0524-5 |
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| author | Fatemeh Haidari Nasrin Banaei-Jahromi Mehrnoosh Zakerkish Kambiz Ahmadi |
| author_facet | Fatemeh Haidari Nasrin Banaei-Jahromi Mehrnoosh Zakerkish Kambiz Ahmadi |
| author_sort | Fatemeh Haidari |
| collection | DOAJ |
| description | Abstract Background Polycystic Ovary Syndrome (PCOS) is known as the most common endocrine disorder of women in reproductive ages. With the increasing prevalence of PCOS in different countries, the use of herbal medicine as an alternative treatment is growing in these patients. This study aimed to evaluate the effects of flaxseed powder supplementation on metabolic biomarkers of patients with PCOS. Methods This randomized open-labeled controlled clinical trial was conducted on 41 patients with PCOS. The participants were randomized to take either flaxseed powder (30 g/day) plus lifestyle modification or only lifestyle modification for 12 weeks. Anthropometric and biochemical evaluations were performed for all patients at the beginning and end of the study. Results The flaxseed group showed a significant reduction in body weight, insulin concentration, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Triglycerides (TG), high-sensitivity C-Reactive Protein (hs-CRP), and leptin and an increase in Quantitative Insulin-Sensitivity Check Index (QUICKI), High Density Lipoprotein (HDL), and adiponectin compared to the baseline (p < 0.05). Flaxseed supplementation also led to a significant reduction in insulin concentration, HOMA-IR, TG, hs-CRP, Interleukin 6 (IL- 6), and leptin and an increase in QUICKI, HDL, and adiponectin compared to the control group (p < 0.05). No significant changes were observed in other parameters. Conclusions Flaxseed supplementation plus lifestyle modification was more effective compared to lifestyle modification alone in biochemical and anthropometric variables in patients with PCOS. Trial registration The trial protocol was approved by the Ethics Board at Ahvaz Jundishapur University of Medical Sciences and was registered at Iranian Registry of Clinical Trials (code: IRCT20120704010181N11). |
| first_indexed | 2024-12-14T05:45:30Z |
| format | Article |
| id | doaj.art-1288e71a208c4ad7bb6a4abe5da8dfbd |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-14T05:45:30Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-1288e71a208c4ad7bb6a4abe5da8dfbd2022-12-21T23:14:53ZengBMCNutrition Journal1475-28912020-01-0119111110.1186/s12937-020-0524-5The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trialFatemeh Haidari0Nasrin Banaei-Jahromi1Mehrnoosh Zakerkish2Kambiz Ahmadi3Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Faculty of Paramedical Sciences, Ahvaz Jundishapur University of Medical SciencesDepartment of Nutrition, Nutrition and Metabolic Diseases Research Center, Faculty of Paramedical Sciences, Ahvaz Jundishapur University of Medical SciencesDepartment of Endocrinology and Metabolism, Faculty of Medicine, Diabetes Research Center, Ahvaz Jundishapur University of Medical SciencesDepartment of Statistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical SciencesAbstract Background Polycystic Ovary Syndrome (PCOS) is known as the most common endocrine disorder of women in reproductive ages. With the increasing prevalence of PCOS in different countries, the use of herbal medicine as an alternative treatment is growing in these patients. This study aimed to evaluate the effects of flaxseed powder supplementation on metabolic biomarkers of patients with PCOS. Methods This randomized open-labeled controlled clinical trial was conducted on 41 patients with PCOS. The participants were randomized to take either flaxseed powder (30 g/day) plus lifestyle modification or only lifestyle modification for 12 weeks. Anthropometric and biochemical evaluations were performed for all patients at the beginning and end of the study. Results The flaxseed group showed a significant reduction in body weight, insulin concentration, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Triglycerides (TG), high-sensitivity C-Reactive Protein (hs-CRP), and leptin and an increase in Quantitative Insulin-Sensitivity Check Index (QUICKI), High Density Lipoprotein (HDL), and adiponectin compared to the baseline (p < 0.05). Flaxseed supplementation also led to a significant reduction in insulin concentration, HOMA-IR, TG, hs-CRP, Interleukin 6 (IL- 6), and leptin and an increase in QUICKI, HDL, and adiponectin compared to the control group (p < 0.05). No significant changes were observed in other parameters. Conclusions Flaxseed supplementation plus lifestyle modification was more effective compared to lifestyle modification alone in biochemical and anthropometric variables in patients with PCOS. Trial registration The trial protocol was approved by the Ethics Board at Ahvaz Jundishapur University of Medical Sciences and was registered at Iranian Registry of Clinical Trials (code: IRCT20120704010181N11).https://doi.org/10.1186/s12937-020-0524-5Polycystic ovary syndromeFlaxseedSex hormone binding globulinInsulin resistanceAdiponectinLeptin |
| spellingShingle | Fatemeh Haidari Nasrin Banaei-Jahromi Mehrnoosh Zakerkish Kambiz Ahmadi The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial Nutrition Journal Polycystic ovary syndrome Flaxseed Sex hormone binding globulin Insulin resistance Adiponectin Leptin |
| title | The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial |
| title_full | The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial |
| title_fullStr | The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial |
| title_full_unstemmed | The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial |
| title_short | The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial |
| title_sort | effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome a randomized open labeled controlled clinical trial |
| topic | Polycystic ovary syndrome Flaxseed Sex hormone binding globulin Insulin resistance Adiponectin Leptin |
| url | https://doi.org/10.1186/s12937-020-0524-5 |
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