Biomimicking design of artificial periosteum for promoting bone healing
Background: Periosteum is a vascularized tissue membrane covering the bone surface and plays a decisive role in bone reconstruction process after fracture. Various artificial periosteum has been developed to assist the allografts or bionic bone scaffolds in accelerating bone healing. Recently, the b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X2200050X |
| _version_ | 1797989943352492032 |
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| author | Yuhe Yang Jingdong Rao Huaqian Liu Zhifei Dong Zhen Zhang Ho-Pan Bei Chunyi Wen Xin Zhao |
| author_facet | Yuhe Yang Jingdong Rao Huaqian Liu Zhifei Dong Zhen Zhang Ho-Pan Bei Chunyi Wen Xin Zhao |
| author_sort | Yuhe Yang |
| collection | DOAJ |
| description | Background: Periosteum is a vascularized tissue membrane covering the bone surface and plays a decisive role in bone reconstruction process after fracture. Various artificial periosteum has been developed to assist the allografts or bionic bone scaffolds in accelerating bone healing. Recently, the biomimicking design of artificial periosteum has attracted increasing attention due to the recapitulation of the natural extracellular microenvironment of the periosteum and has presented unique capacity to modulate the cell fates and ultimately enhance the bone formation and improve neovascularization. Methods: A systematic literature search is performed and relevant findings in biomimicking design of artificial periosteum have been reviewed and cited. Results: We give a systematical overview of current development of biomimicking design of artificial periosteum. We first summarize the universal strategies for designing biomimicking artificial periosteum including biochemical biomimicry and biophysical biomimicry aspects. We then discuss three types of novel versatile biomimicking artificial periosteum including physical-chemical combined artificial periosteum, heterogeneous structured biomimicking periosteum, and healing phase-targeting biomimicking periosteum. Finally, we comment on the potential implications and prospects in the future design of biomimicking artificial periosteum. Conclusion: This review summarizes the preparation strategies of biomimicking artificial periosteum in recent years with a discussion of material selection, animal model adoption, biophysical and biochemical cues to regulate the cell fates as well as three types of latest developed versatile biomimicking artificial periosteum. In future, integration of innervation, osteochondral regeneration, and osteoimmunomodulation, should be taken into consideration when fabricating multifunctional artificial periosteum.The Translational Potential of this Article: This study provides a holistic view on the design strategy and the therapeutic potential of biomimicking artificial periosteum to promote bone healing. It is hoped to open a new avenue of artificial periosteum design with biomimicking considerations and reposition of the current strategy for accelerated bone healing. |
| first_indexed | 2024-04-11T08:28:36Z |
| format | Article |
| id | doaj.art-1289b6ea11f147c48e87996869e96728 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-11T08:28:36Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-1289b6ea11f147c48e87996869e967282022-12-22T04:34:37ZengElsevierJournal of Orthopaedic Translation2214-031X2022-09-01361832Biomimicking design of artificial periosteum for promoting bone healingYuhe Yang0Jingdong Rao1Huaqian Liu2Zhifei Dong3Zhen Zhang4Ho-Pan Bei5Chunyi Wen6Xin Zhao7Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China; Faculty of Science, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China; Corresponding author.Background: Periosteum is a vascularized tissue membrane covering the bone surface and plays a decisive role in bone reconstruction process after fracture. Various artificial periosteum has been developed to assist the allografts or bionic bone scaffolds in accelerating bone healing. Recently, the biomimicking design of artificial periosteum has attracted increasing attention due to the recapitulation of the natural extracellular microenvironment of the periosteum and has presented unique capacity to modulate the cell fates and ultimately enhance the bone formation and improve neovascularization. Methods: A systematic literature search is performed and relevant findings in biomimicking design of artificial periosteum have been reviewed and cited. Results: We give a systematical overview of current development of biomimicking design of artificial periosteum. We first summarize the universal strategies for designing biomimicking artificial periosteum including biochemical biomimicry and biophysical biomimicry aspects. We then discuss three types of novel versatile biomimicking artificial periosteum including physical-chemical combined artificial periosteum, heterogeneous structured biomimicking periosteum, and healing phase-targeting biomimicking periosteum. Finally, we comment on the potential implications and prospects in the future design of biomimicking artificial periosteum. Conclusion: This review summarizes the preparation strategies of biomimicking artificial periosteum in recent years with a discussion of material selection, animal model adoption, biophysical and biochemical cues to regulate the cell fates as well as three types of latest developed versatile biomimicking artificial periosteum. In future, integration of innervation, osteochondral regeneration, and osteoimmunomodulation, should be taken into consideration when fabricating multifunctional artificial periosteum.The Translational Potential of this Article: This study provides a holistic view on the design strategy and the therapeutic potential of biomimicking artificial periosteum to promote bone healing. It is hoped to open a new avenue of artificial periosteum design with biomimicking considerations and reposition of the current strategy for accelerated bone healing.http://www.sciencedirect.com/science/article/pii/S2214031X2200050XArtificial periosteumBiomimicking designBiochemical biomimicryBiophysical biomimicryBone regeneration |
| spellingShingle | Yuhe Yang Jingdong Rao Huaqian Liu Zhifei Dong Zhen Zhang Ho-Pan Bei Chunyi Wen Xin Zhao Biomimicking design of artificial periosteum for promoting bone healing Journal of Orthopaedic Translation Artificial periosteum Biomimicking design Biochemical biomimicry Biophysical biomimicry Bone regeneration |
| title | Biomimicking design of artificial periosteum for promoting bone healing |
| title_full | Biomimicking design of artificial periosteum for promoting bone healing |
| title_fullStr | Biomimicking design of artificial periosteum for promoting bone healing |
| title_full_unstemmed | Biomimicking design of artificial periosteum for promoting bone healing |
| title_short | Biomimicking design of artificial periosteum for promoting bone healing |
| title_sort | biomimicking design of artificial periosteum for promoting bone healing |
| topic | Artificial periosteum Biomimicking design Biochemical biomimicry Biophysical biomimicry Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X2200050X |
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