Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency

Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency

Abstract Background Ornithine transcarbamylase deficiency (OTCD) is most common among urea cycle disorders (UCDs), defined by defects in enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, including OTCD patients, is suggested to be avoided, as it may induce life-thre...

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Main Authors: Koji Imoto, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Shigeki Tashiro, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Gastroenterology
Subjects:
Ornithine transcarbamylase deficiency
Corticosteroid
Hyperammonemia
Urea cycle disorder
Late-onset ornithine transcarbamylase deficiency
Online Access:https://doi.org/10.1186/s12876-022-02213-0

Internet

https://doi.org/10.1186/s12876-022-02213-0

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