Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?
<p>Abstract</p> <p>Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. We now address the issue, focusing on the temporal changes having occurred: most patients in recent RCTs are no longer n-3...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-01-01
|
| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1741-7015/11/5 |
| _version_ | 1819041828099325952 |
|---|---|
| author | de Lorgeril Michel Salen Patricia Defaye Pascal Rabaeus Mikael |
| author_facet | de Lorgeril Michel Salen Patricia Defaye Pascal Rabaeus Mikael |
| author_sort | de Lorgeril Michel |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. We now address the issue, focusing on the temporal changes having occurred: most patients in recent RCTs are no longer n-3 deficient and the vast majority are now treated with statins. Recent RCTs testing n-3 against arrhythmias suggest that n-3 reduce the risk only in patients not taking a statin. Other recent RCTs in secondary prevention were negative although, in a <it>post-hoc </it>analysis separating statin users and non-users, non-significant protection of n-3 was observed among statin non-users whereas statin users had no effect. Recent RCTs testing statins - after the implementation of the New Clinical Trial Regulation in 2007 - are negative (or flawed) suggesting that the lack of effect of n-3 cannot be attributed to a parallel protection by statins. Finally, statins favor the metabolism of omega-6 fatty acids (n-6), which in turn inhibits n-3 and, contrary to n-3, they increase insulin resistance and the risk of diabetes. Thus, n-3 and statins are counteractive at several levels and statins appear to inhibit n-3.</p> |
| first_indexed | 2024-12-21T09:31:11Z |
| format | Article |
| id | doaj.art-128b6360354c41e8abbf6431ea8e32b0 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-21T09:31:11Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-128b6360354c41e8abbf6431ea8e32b02022-12-21T19:08:45ZengBMCBMC Medicine1741-70152013-01-01111510.1186/1741-7015-11-5Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?de Lorgeril MichelSalen PatriciaDefaye PascalRabaeus Mikael<p>Abstract</p> <p>Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. We now address the issue, focusing on the temporal changes having occurred: most patients in recent RCTs are no longer n-3 deficient and the vast majority are now treated with statins. Recent RCTs testing n-3 against arrhythmias suggest that n-3 reduce the risk only in patients not taking a statin. Other recent RCTs in secondary prevention were negative although, in a <it>post-hoc </it>analysis separating statin users and non-users, non-significant protection of n-3 was observed among statin non-users whereas statin users had no effect. Recent RCTs testing statins - after the implementation of the New Clinical Trial Regulation in 2007 - are negative (or flawed) suggesting that the lack of effect of n-3 cannot be attributed to a parallel protection by statins. Finally, statins favor the metabolism of omega-6 fatty acids (n-6), which in turn inhibits n-3 and, contrary to n-3, they increase insulin resistance and the risk of diabetes. Thus, n-3 and statins are counteractive at several levels and statins appear to inhibit n-3.</p>http://www.biomedcentral.com/1741-7015/11/5omega-3 fatty acidsstatinsischemic heart diseasemyocardial infarctionrandomized clinical trialsepidemiologymitochondriainsulin resistancediabetesn-6 fatty acids |
| spellingShingle | de Lorgeril Michel Salen Patricia Defaye Pascal Rabaeus Mikael Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? BMC Medicine omega-3 fatty acids statins ischemic heart disease myocardial infarction randomized clinical trials epidemiology mitochondria insulin resistance diabetes n-6 fatty acids |
| title | Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? |
| title_full | Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? |
| title_fullStr | Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? |
| title_full_unstemmed | Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? |
| title_short | Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? |
| title_sort | recent findings on the health effects of omega 3 fatty acids and statins and their interactions do statins inhibit omega 3 |
| topic | omega-3 fatty acids statins ischemic heart disease myocardial infarction randomized clinical trials epidemiology mitochondria insulin resistance diabetes n-6 fatty acids |
| url | http://www.biomedcentral.com/1741-7015/11/5 |
| work_keys_str_mv | AT delorgerilmichel recentfindingsonthehealtheffectsofomega3fattyacidsandstatinsandtheirinteractionsdostatinsinhibitomega3 AT salenpatricia recentfindingsonthehealtheffectsofomega3fattyacidsandstatinsandtheirinteractionsdostatinsinhibitomega3 AT defayepascal recentfindingsonthehealtheffectsofomega3fattyacidsandstatinsandtheirinteractionsdostatinsinhibitomega3 AT rabaeusmikael recentfindingsonthehealtheffectsofomega3fattyacidsandstatinsandtheirinteractionsdostatinsinhibitomega3 |