FOXM1-AKT Positive Regulation Loop Provides Venetoclax Resistance in AML

FOXM1-AKT Positive Regulation Loop Provides Venetoclax Resistance in AML

Forkhead box protein M1 (FOXM1) is a crucial regulator of cancer development and chemoresistance. It is often overexpressed in acute myeloid leukemia (AML) and is associated with poor survival and reduced efficacy of cytarabine therapy. Molecular mechanisms underlying high FOXM1 expression levels in...

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Bibliographic Details
Main Authors: Mikhail S Chesnokov, Soheila Borhani, Marianna Halasi, Zarema Arbieva, Irum Khan, Andrei L. Gartel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
FOXM1
AKT pathway
acute myeloid leukemia
positive feedback loop
drug resistance
HOXA gene family
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.696532/full

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