Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile
ABSTRACT The objective of this preliminary study was to correlate diffusion tensor imaging (DTI) alterations with the cognitive profile of patients with amyotrophic lateral sclerosis (ALS). Methods This was a case-control study conducted from December 1, 2012 to December 1, 2014. Clinical and demo...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000500272&lng=en&tlng=en |
| _version_ | 1818172333655851008 |
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| author | Marcelo Chaves Mariela Bettini Maria Cecilia Fernandez Maria Jose Garcia Basalo Juan Ignacio Rojas Cristina Besada Edgardo Cristiano Angel Golimstok Marcelo Rugiero |
| author_facet | Marcelo Chaves Mariela Bettini Maria Cecilia Fernandez Maria Jose Garcia Basalo Juan Ignacio Rojas Cristina Besada Edgardo Cristiano Angel Golimstok Marcelo Rugiero |
| author_sort | Marcelo Chaves |
| collection | DOAJ |
| description | ABSTRACT The objective of this preliminary study was to correlate diffusion tensor imaging (DTI) alterations with the cognitive profile of patients with amyotrophic lateral sclerosis (ALS). Methods This was a case-control study conducted from December 1, 2012 to December 1, 2014. Clinical and demographic data were recorded. A neuropsychological test battery adapted to ALS patients was used. An MRI with DTI was performed in all patients and fractional anisotropy (FA) was analyzed in the white matter using the tract based spatial statistics program. Results Twenty-four patients with ALS (15 females, mean age 66.9 + -2.3) and 13 healthy controls (four females, average age 66.9 + - 2) were included. The DTI showed white matter damage in ALS patients vs. healthy controls (p < 0.001). Discussion In our preliminary study the alterations of white matter in DTI were significantly associated with cognitive impairment in patients with ALS. |
| first_indexed | 2024-12-11T19:10:57Z |
| format | Article |
| id | doaj.art-128dc7bdf9f1451887f347069de7d6b9 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-11T19:10:57Z |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-128dc7bdf9f1451887f347069de7d6b92022-12-22T00:53:47ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-422775527227610.1590/0004-282x20170032S0004-282X2017000500272Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profileMarcelo ChavesMariela BettiniMaria Cecilia FernandezMaria Jose Garcia BasaloJuan Ignacio RojasCristina BesadaEdgardo CristianoAngel GolimstokMarcelo RugieroABSTRACT The objective of this preliminary study was to correlate diffusion tensor imaging (DTI) alterations with the cognitive profile of patients with amyotrophic lateral sclerosis (ALS). Methods This was a case-control study conducted from December 1, 2012 to December 1, 2014. Clinical and demographic data were recorded. A neuropsychological test battery adapted to ALS patients was used. An MRI with DTI was performed in all patients and fractional anisotropy (FA) was analyzed in the white matter using the tract based spatial statistics program. Results Twenty-four patients with ALS (15 females, mean age 66.9 + -2.3) and 13 healthy controls (four females, average age 66.9 + - 2) were included. The DTI showed white matter damage in ALS patients vs. healthy controls (p < 0.001). Discussion In our preliminary study the alterations of white matter in DTI were significantly associated with cognitive impairment in patients with ALS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000500272&lng=en&tlng=enTensor de difusiónesclerosis lateral amiotróficabiomarcadores |
| spellingShingle | Marcelo Chaves Mariela Bettini Maria Cecilia Fernandez Maria Jose Garcia Basalo Juan Ignacio Rojas Cristina Besada Edgardo Cristiano Angel Golimstok Marcelo Rugiero Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile Arquivos de Neuro-Psiquiatria Tensor de difusión esclerosis lateral amiotrófica biomarcadores |
| title | Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile |
| title_full | Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile |
| title_fullStr | Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile |
| title_full_unstemmed | Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile |
| title_short | Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile |
| title_sort | usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis potential biomarker and association with the cognitive profile |
| topic | Tensor de difusión esclerosis lateral amiotrófica biomarcadores |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000500272&lng=en&tlng=en |
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