Non-opioid analgesics in contemporary treatment of pain
Pain is a symptom of most diseases that can significantly impair the patient's quality of life. In many diseases it is impossible to eliminate the cause of pain therefore the real goal of treatment is the removal of pain as a symptom, by application of analgesics. Contemporary pharmacotherapy e...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2019-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901021T.pdf |
| _version_ | 1819077413616746496 |
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| author | Tomić Maja Pecikoza Uroš Micov Ana |
| author_facet | Tomić Maja Pecikoza Uroš Micov Ana |
| author_sort | Tomić Maja |
| collection | DOAJ |
| description | Pain is a symptom of most diseases that can significantly impair the patient's quality of life. In many diseases it is impossible to eliminate the cause of pain therefore the real goal of treatment is the removal of pain as a symptom, by application of analgesics. Contemporary pharmacotherapy employs conventional (opioid and non-opioid analgesics - NSAIDs and paracetamol) and adjuvant analgesics (antiepileptics, antidepressants and others). Analgesic effect of non-opioid analgesics is mainly the consequence of prostaglandin synthesis inhibition. They are effective for pain of mild/moderate intensity. In acute pain there is no difference in efficiency between NSAIDs and paracetamol, so the choice of the drug is individual. In chronic pain, when inflammation is present, NSAIDs are more effective than paracetamol. Long-term use of high doses of NSAIDs is often accompanied by side effects. In order to reduce their frequency, a careful assessment of risk for each patient should be made, a drug with a low risk of certain side effects should be chosen, the dose and duration of treatment should be limited and the possibility of topical application should be considered. The need for long-term use of NSAIDs should be reviewed periodically. |
| first_indexed | 2024-12-21T18:56:48Z |
| format | Article |
| id | doaj.art-128f3147530942ddbffe4357c796ad70 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-12-21T18:56:48Z |
| publishDate | 2019-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-128f3147530942ddbffe4357c796ad702022-12-21T18:53:36ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672019-01-01691102110310004-19631901021TNon-opioid analgesics in contemporary treatment of painTomić Maja0Pecikoza Uroš1Micov Ana2Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za farmakologiju, BeogradUniverzitet u Beogradu, Farmaceutski fakultet, Katedra za farmakologiju, BeogradUniverzitet u Beogradu, Farmaceutski fakultet, Katedra za farmakologiju, BeogradPain is a symptom of most diseases that can significantly impair the patient's quality of life. In many diseases it is impossible to eliminate the cause of pain therefore the real goal of treatment is the removal of pain as a symptom, by application of analgesics. Contemporary pharmacotherapy employs conventional (opioid and non-opioid analgesics - NSAIDs and paracetamol) and adjuvant analgesics (antiepileptics, antidepressants and others). Analgesic effect of non-opioid analgesics is mainly the consequence of prostaglandin synthesis inhibition. They are effective for pain of mild/moderate intensity. In acute pain there is no difference in efficiency between NSAIDs and paracetamol, so the choice of the drug is individual. In chronic pain, when inflammation is present, NSAIDs are more effective than paracetamol. Long-term use of high doses of NSAIDs is often accompanied by side effects. In order to reduce their frequency, a careful assessment of risk for each patient should be made, a drug with a low risk of certain side effects should be chosen, the dose and duration of treatment should be limited and the possibility of topical application should be considered. The need for long-term use of NSAIDs should be reviewed periodically.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901021T.pdfpainnon-opioid analgesicsnonsteroidal anti-inflammatory drugs - NSAIDsparacetamol |
| spellingShingle | Tomić Maja Pecikoza Uroš Micov Ana Non-opioid analgesics in contemporary treatment of pain Arhiv za farmaciju pain non-opioid analgesics nonsteroidal anti-inflammatory drugs - NSAIDs paracetamol |
| title | Non-opioid analgesics in contemporary treatment of pain |
| title_full | Non-opioid analgesics in contemporary treatment of pain |
| title_fullStr | Non-opioid analgesics in contemporary treatment of pain |
| title_full_unstemmed | Non-opioid analgesics in contemporary treatment of pain |
| title_short | Non-opioid analgesics in contemporary treatment of pain |
| title_sort | non opioid analgesics in contemporary treatment of pain |
| topic | pain non-opioid analgesics nonsteroidal anti-inflammatory drugs - NSAIDs paracetamol |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901021T.pdf |
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